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Tang, J.; Zhang, Y.; Yang, L.; Chen, Q.; Tan, L.; Zuo, S.; Feng, H.; Chen, Z.; Zhu, G. |
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Title |
Exposure to 900MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats |
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Year |
2015 |
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Brain Research |
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1601 |
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30 |
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92-101 |
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Blood brain barrier; Electromagnetic field; albumin extravasation; electromagnetic fi eld; mkp-1/ERK pathway; spatial memory |
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Elsevier |
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WP5 In vitro; WP6 In vivo |
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UNIBAS @ david.schuermann @ |
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612 |
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Author |
Tomasetti, C.; Vogelstein, B. |
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Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions |
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Journal Article |
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Year |
2015 |
Publication |
Science (New York, N.Y.) |
Abbreviated Journal |
Science |
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Volume |
347 |
Issue |
6217 |
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78-81 |
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Abstract |
Some tissue types give rise to human cancers millions of times more often than other tissue types. Although this has been recognized for more than a century, it has never been explained. Here, we show that the lifetime risk of cancers of many different types is strongly correlated (0.81) with the total number of divisions of the normal self-renewing cells maintaining that tissue's homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to “bad luck,” that is, random mutations arising during DNA replication in normal, noncancerous stem cells. This is important not only for understanding the disease but also for designing strategies to limit the mortality it causes. |
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Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, Baltimore, MD 21205, USA. ctomasetti@jhu.edu vogelbe@jhmi.edu |
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0036-8075 |
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PMID:25554788 |
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CBM.UAM @ ccobaleda @ |
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538 |
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Author |
Zhang, Y.; Liu, X.; Zhang, J.; Li, N. |
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Title |
Short-term effects of extremely low frequency electromagnetic fields exposure on Alzheimer's disease in rats |
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Journal Article |
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Year |
2015 |
Publication |
International Journal of Radiation Biology |
Abbreviated Journal |
Int J Radiat Biol |
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91 |
Issue |
1 |
Pages |
28-34 |
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Keywords |
Extremely low frequency; cognition and memory; electromagnetic fields; rat |
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Abstract Purpose: With the development and widespread use of electromagnetic field (EMF) technology, recent studies are focusing on the effects of EMF on human health. Recently, extremely low frequency electromagnetic fields (ELF-EMF) have been studied with great interest due to their possible effects on Alzheimer's disease (AD). The objective of the present study was to investigate the interaction between ELF-EMF exposure and memory impairment in rats. MATERIALS AND METHODS: Twenty healthy male Sprague Dawley (SD) rats were randomly divided into two groups (n = 10). Animals were exposed to 100 muT/50 Hz ELF-EMF or subjected to sham exposure when 12 weeks old. After 12 weeks, the Morris water maze (MWM) was used to test the changes in cognitive and memory ability. Amyloid-beta (Abeta) content in cortex, hippocampus and plasma were measured by ELISA assays. The morphology of neuron was detected by H&E staining. RESULTS: After exposure, the body weight of rats showed no difference compared with the control group. The application of ELF-EMF did not induce any cognitive and memory impairment compared with the sham-exposure group. The determination of Abeta showed no significant change between the two groups, and there was no histological change in ELF-EMF exposure group. CONCLUSION: The present study indicated that short-term exposure of 100 muT/50 Hz ELF-EMF had no effects on cognition and memory of rats, and did not alter the expression of Abeta and the neuron morphology. However, more comprehensive studies are still required to elucidate the possible effects and underlying mechanisms of ELF-EMF exposure on living organisms. |
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High Voltage Research Institute, China Electric Power Research Institute , Wuhan , P. R. China |
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0955-3002 |
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PMID:25118893 |
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CBM.UAM @ ccobaleda @ |
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602 |
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