| Record |
Author  |
Baum, A.; Mevissen, M.; Kamino, K.; Mohr, U.; Loscher, W. |
| Title |
A histopathological study on alterations in DMBA-induced mammary carcinogenesis in rats with 50 Hz, 100 muT magnetic field exposure |
Type |
Journal Article |
| Year |
1995 |
Publication |
Carcinogenesis |
Abbreviated Journal |
Carcinogenesis |
| Volume |
16 |
Issue |
1 |
Pages |
119-125 |
| Keywords |
*9,10-Dimethyl-1,2-benzanthracene; Animals; Behavior, Animal/drug effects; *Cocarcinogenesis; Electromagnetic Fields/*adverse effects; Female; Hyperplasia/chemically induced/etiology; Magnetics/*adverse effects; Mammary Glands, Animal/drug effects/pathology; Mammary Neoplasms, Experimental/chemically induced/*etiology/*pathology; Methylnitrosourea; Rats; Rats, Sprague-Dawley |
| Abstract |
Several epidemiological studies have indicated that residential or occupational exposure to 50 or 60 Hz magnetic fields (MF) may increase the risk of breast cancer, possibly by suppression of pineal production of the oncostatic hormone melatonin. In view of the methodological problems of epidemiological studies on MF exposure and cancer risk, laboratory studies are needed to determine whether 50/60 Hz exposure can initiate, promote or copromote mammary cancer. In the present study, 216 female Sprague-Dawley rats were divided into four groups. Two of the groups (with 99 animals each) received oral applications of 7,12-dimethylbenz[a]anthracene (DMBA) and were either sham-exposed or exposed in a 50 Hz, 100 muT MF for 24 h/day 7 days/week for a period of 91 days. The other two groups (nine animals each) were either sham-exposed or MF-exposed without DMBA treatment. The exposure chambers and all other environmental factors were identical for MF-exposed and sham-exposed animals. At the end of the 3 month period of MF exposure, all rats were used for histopathological diagnosis of lesions. At the time of necropsy, significantly more MF-exposed DMBA-treated rats exhibited macroscopically visible mammary tumours than DMBA-treated controls. Furthermore, the size of mammary tumours was significantly larger in MF-exposed rats. Histopathological examination of the mammary gland showed that the number of neoplastic and non-neoplastic lesions did not significantly differ between groups, indicating that MF exposure had not altered the incidence of mammary lesions but had only accelerated tumour growth, consistent with a co-promoting effect. In the MF-exposed group, significantly more rats exhibited malignant mammary tumours than in controls, indicating that MF exposure had affected the progression of DMBA-induced lesions. The number of metastases of mammary tumours or of primary lesions in other organs in response to DMBA was not affected by MF exposure. In rats without DMBA application, no non-neoplastic or neoplastic lesions were determined. The data demonstrate that long-term exposure of DMBA-treated female rats promotes the growth and progression of mammary tumours, while tumour incidence is not affected, at least under the experimental conditions of the present study. The data thus add to the accumulating evidence that MF exposure exerts tumour co-promoting effects. |
| Address |
Institute of Experimental Pathology, Medical School Hannover, Germany |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0143-3334 |
ISBN |
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Medium |
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| Area |
WP6 In vivo |
Expedition |
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Conference |
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| Notes |
PMID:7834796 |
Approved |
no |
| Call Number |
ITEM @ geertje.lewin @ |
Serial |
141 |
| Permanent link to this record |
