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Author (up) Marley, R.; Giachello, C.N.G.; Scrutton, N.S.; Baines, R.A.; Jones, A.R. url  openurl
  Title Cryptochrome-dependent magnetic field effect on seizure response in Drosophila larvae Type Journal Article
  Year 2014 Publication Scientific Reports Abbreviated Journal Sci Rep  
  Volume 4 Issue Pages 5799  
  Abstract The mechanisms that facilitate animal magnetoreception have both fascinated and confounded scientists for decades, and its precise biophysical origin remains unclear. Among the proposed primary magnetic sensors is the flavoprotein, cryptochrome, which is thought to provide geomagnetic information via a quantum effect in a light-initiated radical pair reaction. Despite recent advances in the radical pair model of magnetoreception from theoretical, molecular and animal behaviour studies, very little is known of a possible signal transduction mechanism. We report a substantial effect of magnetic field exposure on seizure response in Drosophila larvae. The effect is dependent on cryptochrome, the presence and wavelength of light and is blocked by prior ingestion of typical antiepileptic drugs. These data are consistent with a magnetically-sensitive, photochemical radical pair reaction in cryptochrome that alters levels of neuronal excitation, and represent a vital step forward in our understanding of the signal transduction mechanism involved in animal magnetoreception.  
  Corporate Author Thesis  
  Publisher Nature Publishing Group Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2045-2322 ISBN Medium  
  Area WP5 In vitro; WP6 In vivo Expedition Conference  
  Notes Approved no  
  Call Number UNIBAS @ david.schuermann @ Serial 636  
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