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Kuster, N. |
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Title |
Increasing Bias towards False Negative Replications? |
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Journal Article |
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2011 |
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BEMS NEWSLETTER, www.bems.org |
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217 |
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1-5 |
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WP9 Epidemiology |
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IT'IS @ kuster @ Kuster:2011tt |
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20 |
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Bernstein, B.E.; Meissner, A.; Lander, E.S. |
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Title |
The mammalian epigenome |
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Journal Article |
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2007 |
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Cell |
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128 |
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4 |
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669-681 |
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Animals; Chromatin Assembly and Disassembly/*genetics; CpG Islands/genetics; DNA Methylation; Epigenesis, Genetic/*genetics; Gene Expression Regulation, Developmental/genetics; Genomic Instability/*genetics; Histones/genetics/metabolism; Humans; Mammals/*genetics |
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Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and environment. With the sequencing of the human genome completed, investigators now seek a comprehensive view of the epigenetic changes that determine how genetic information is made manifest across an incredibly varied background of developmental stages, tissue types, and disease states. Here we review current research efforts, with an emphasis on large-scale studies, emerging technologies, and challenges ahead. |
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0092-8674 |
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WP5 In vitro |
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PMID: 17320505 |
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UNIBAS @ david.schuermann @ Bernstein2007 |
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70 |
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Joachim Schüz, Jan-Peter Grigat, Bernd Störmer, Gerd Rippin, Karl Brinkmann and Jörg Michaelis |
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Extremely low frequency magnetic fields in residences in Germany. Distribution of measurements, comparison of two methods for assessing exposure, and predictors for the occurrence of magnetic fields above background level |
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2000 |
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39 |
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4 |
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233-240 |
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We examined the results of 1,835 magnetic field measurements in German residences conducted between November 1997 and September 1999. The measurements were part of an epidemiological study on the relationship between magnetic fields and childhood leukemia. We performed a fixed-location measurement of the magnetic field at 50 Hz and 16 2/3 Hz (frequency of the German railway system) over 24 h in the child’s bedroom in the residence of each study participant. In addition, we conducted a second 24 h-measurement in the living room at 50 Hz, and spot measurements while
walking through all rooms of the respective dwelling.
Median 50 Hz magnetic fields above 0.2 µT were found to be infrequent in Germany (only 1.4% of all residences). Fields produced by high-voltage power lines
(123–420 kV) were lower than expected: the median magnetic field was above 0.2 µT in only 8 (32.0%) of 25 residences located 50 m or closer to a high-voltage
power line indicating that power lines in Germany are usually run well below the maximum power load. We found that magnetic fields were correlated with the type
of residence and higher magnetic fields were measured in apartment buildings. There was also some evidence for a positive correlation between magnetic fields and
traffic density and an inverse association between magnetic fields and family net income. The 24 h-magnetic field measurements correlated well with the spot measurements (r>0.7). However, when dichotomized with a cut-off point of 0.2 µT, there was only a poor agreement between the two measurement methods. A loss of the
strength of the association after categorization was also observed when comparing the arithmetic mean and median of the same 24 h-measurement. In summary, these analyses give a valuable overview of magnetic field distributions in German residences. |
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CNR-ISIB @ paolo.ravazzani @ |
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145 |
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Kris Caputa and Maria A. Stuchly. |
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Computer Controlled System for Producing Uniform Magnetic Fields and its Application in Biomedical Research |
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1996 |
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IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT |
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45 |
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3 |
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701-705 |
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WP3 Exposure Systems, Dosimetry and Quality Control |
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ITIS @ gong @ |
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174 |
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James R. Gauger, Tim R. Johnson, James E. Stangel, Robert C. Patterson, Dean A. Williams, J. Brooks Harder, and David L. McCormick |
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Title |
Design, Construction, and Validation of a Large Capacity Rodent Magnetic Field Exposure Laboratory |
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Year |
1999 |
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Bioelectromagnetics |
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20 |
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13-23 |
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WP3 Exposure Systems |
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ITIS @ gong @ |
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175 |
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