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Kuster, N.; Torres, V.B.; Nikoloski, N.; Frauscher, M.; Kainz, W. |
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Title |
Methodology of detailed dosimetry and treatment of uncertainty and variations for in vivo studies |
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2006 |
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Bioelectromagnetics |
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Bioelectromagnetics |
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27 |
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5 |
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378-391 |
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0197-8462 |
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IT'IS @ kuster @ |
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27 |
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Kuster, N. |
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Title |
Increasing Bias towards False Negative Replications? |
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2011 |
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BEMS NEWSLETTER, www.bems.org |
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217 |
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1-5 |
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WP9 Epidemiology |
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ian |
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IT'IS @ kuster @ Kuster:2011tt |
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20 |
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European Health Risk Assessment Network on Electromagnetic Fields Exposure |
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D3 – Report on the analysis of risks associated to exposure to EMF: in vitro and in vivo (animals) studies |
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2010 |
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EFHRAN |
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IT'IS @ kuster @ |
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53 |
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Anderson, K.; Lutz, C.; van Delft, F.W.; Bateman, C.M.; Guo, Y.; Colman, S.M.; Kempski, H.; Moorman, A.V.; Titley, I.; Swansbury, J.; Kearney, L.; Enver, T.; Greaves, M. |
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Title |
Genetic variegation of clonal architecture and propagating cells in leukaemia |
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Journal Article |
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2011 |
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Nature |
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Nature |
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469 |
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7330 |
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356-361 |
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Animals; Clone Cells/metabolism/*pathology; DNA Copy Number Variations/genetics; DNA Mutational Analysis; Disease Progression; Genetic Variation/*genetics; Genotype; Humans; Immunophenotyping; In Situ Hybridization, Fluorescence; Interleukin Receptor Common gamma Subunit/deficiency/genetics; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Oncogene Proteins, Fusion/genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/*pathology |
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Abstract |
Little is known of the genetic architecture of cancer at the subclonal and single-cell level or in the cells responsible for cancer clone maintenance and propagation. Here we have examined this issue in childhood acute lymphoblastic leukaemia in which the ETV6-RUNX1 gene fusion is an early or initiating genetic lesion followed by a modest number of recurrent or 'driver' copy number alterations. By multiplexing fluorescence in situ hybridization probes for these mutations, up to eight genetic abnormalities can be detected in single cells, a genetic signature of subclones identified and a composite picture of subclonal architecture and putative ancestral trees assembled. Subclones in acute lymphoblastic leukaemia have variegated genetics and complex, nonlinear or branching evolutionary histories. Copy number alterations are independently and reiteratively acquired in subclones of individual patients, and in no preferential order. Clonal architecture is dynamic and is subject to change in the lead-up to a diagnosis and in relapse. Leukaemia propagating cells, assayed by serial transplantation in NOD/SCID IL2Rgamma(null) mice, are also genetically variegated, mirroring subclonal patterns, and vary in competitive regenerative capacity in vivo. These data have implications for cancer genomics and for the targeted therapy of cancer. |
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Section of Haemato-Oncology, The Institute of Cancer Research, Sutton SM2 5NG, UK |
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English |
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0028-0836 |
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WP6 In vivo |
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PMID:21160474 |
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CBM.UAM @ ccobaleda @ |
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28 |
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Schuderer, J; Oesch, W.; Felber, N.; Spät, D.; Kuster, N. |
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Title |
In vitro exposure apparatus for ELF magnetic fields |
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Journal Article |
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Year |
2004 |
Publication |
Bioelectromagnetics |
Abbreviated Journal |
Bioelectromagnetics |
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25 |
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8 |
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582-591 |
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For in vitro studies on the effect of extremely low frequency (ELF) magnetic field exposures in different laboratories, a programmable, high precision exposure system enabling blinded exposures has been developed and fully characterized. It is based on two shielded 4 coil systems that fit inside a commercial incubator. The volume of uniform B field exposure with 1% field tolerance is 50% larger compared to a Merrit 4 coil system with the same coil volume. The uncertainties for the applied magnetic fields have been specified to be less than 4%. The computer controlled apparatus allows signal waveforms that are composed of several harmonics, blind protocols, monitoring of exposure and environmental conditions and the application of B fields up to 3.6 mT root-mean-square amplitude. Sources of artifacts have been characterized: sham isolation >43 dB, parasitic incident E fields <1 V/m, no recognizable temperature differences in the media for exposure or sham state, and vibrations of the mechanically decoupled dish holder <0.1 m/s2 (= 0.01 g), which is only twice the sham acceleration background level produced by the incubator and fan vibrations. Bioelectromagnetics 25:582–591, 2004. © 2004 Wiley-Liss, Inc. |
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0197-8462 |
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Call Number |
IT'IS @ kuster @ |
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22 |
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