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Author  |
Wang, T.; Nie, Y.; Zhao, S.; Han, Y.; Du, Y.; Hou, Y. |
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Title |
Involvement of midkine expression in the inhibitory effects of low-frequency magnetic fields on cancer cells |
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Journal Article |
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Year |
2011 |
Publication |
Bioelectromagnetics |
Abbreviated Journal |
Bioelectromagnetics |
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Volume |
32 |
Issue |
6 |
Pages |
443-452 |
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Keywords |
Adenocarcinoma/metabolism/pathology/therapy/ultrastructure; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytokines/genetics/metabolism; Flow Cytometry; Glycoproteins/genetics/metabolism; Humans; *Magnetic Field Therapy; S Phase; Sincalide/genetics/metabolism; Stomach Neoplasms/metabolism/pathology/therapy/ultrastructure |
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Abstract |
Effects of magnetic fields (MFs) on cancer cells may depend on cell type and exposure conditions. Gene expression levels are different among cancer cells. However, the effect of MFs on cancer cells with different gene expressions is still unclear. In this study, the cancer cell lines BGC-823, MKN-45, MKN-28, A549, SPC-A1, and LOVO were exposed to a low-frequency MF. Specific parameters of MFs were determined. Furthermore, the potential of the MF to influence cancer cell growth with midkine (MK) expression was evaluated. Cell proliferation and cell cycle were detected using the CCK-8 assay and flow cytometry. Cell ultrastructure was observed by transmission electron microscopy. BGC-823 cells with over-expression of MK (BGC-MK cells) and stanniocalcin-1 were generated by plasmid construction and transfection. Results showed that exposure to a 0.4-T, 7.5 Hz MF inhibited the proliferation of BGC-823, MKN-28, A549, and LOVO cells, but not MKN-45 and SPC-A1 cells. Moreover, the inhibitory effect of the MF on BGC-MK cells was lower (12.3%) than that of BGC-823 cells (20.3%). Analysis of the cell cycle showed that exposure to the MF led to a significant increase in the S phase in BGC-823 cells, but not in BGC-MK cells. In addition, organelle morphology was modified in BGC-823 cells exposed to the MF. These results suggest that exposure to a 0.4-T, 7.5 Hz MF could inhibit tumor cell proliferation and disturb the cell cycle. The alteration of MK expression in cancer cells may be related to the inhibitory effect of the MF on these cells. |
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Immunology and Reproduction Biology Lab, Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China |
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0197-8462 |
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PMID:21360556 |
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Call Number |
IT'IS @ evaj @ |
Serial |
430 |
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Author |
Wan, G.-jun; Jiang, S.-lin; Zhao, Z.-chao; Xu, J.-jing; Tao, X.-rong; Sword, G. a.; Gao, Y.-bo; Pan, W.-dong; Chen, F.-jun |
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Title |
Bio-effects of near-zero magnetic fields on the growth, development and reproduction of small brown planthopper, Laodelphax striatellus and brown planthopper, Nilaparvata lugens |
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Journal Article |
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Year |
2014 |
Publication |
Journal of Insect Physiology |
Abbreviated Journal |
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Volume |
68 |
Issue |
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Pages |
7-15 |
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Keywords |
near-zero magnetic fields |
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Abstract |
Magnetic fields markedly affect the growth and development of many species of organisms potentially due to cryptochrome and endogenous presence of magnetic materials. Sensitivity to magnetic fields can also be involved in geomagnetic orientation by some long-distance migratory insects. In this study, near-zero magnetic fields (NZMF) in relation to normal geomagnetic fields (GMF) were setup using the Hypomagnetic Field Space System (HMFs) to investigate the effects of magnetic fields on the growth, development and reproduction of two species of migratory planthopper, the small brown planthopper (abbr. SBPH), Laodelphax striatellus, and the brown planthopper (abbr. BPH), Nilaparvata lugens. Exposure of both L. striatellus and N. lugens to NZMF delayed egg and nymphal developmental durations and decreased adult weight and female fecundity. The 1st–5th instars of SBPH and BPH showed different responses to NZMF. The 4th instar was significantly affected by NZMF, especially for BPH males, in which NZMF exposure reduced the difference in development duration between females and males. Compared with GMF, the vitellogenin transcript levels of newly molted female adults and the number of eggs per female were significantly reduced in both planthopper species, indicating a negative effect on fertility under NZMF. Our findings provided experimental evidence that NZMF negatively affected the growth and development of SBPH and BPH, with particularly strong effects on reproduction. |
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Elsevier Ltd |
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UNIBAS @ david.schuermann @ |
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603 |
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Author |
Walters, Z.B. |
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Title |
Quantum dynamics of the avian compass |
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Journal Article |
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Year |
2014 |
Publication |
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics |
Abbreviated Journal |
Phys Rev E Stat Nonlin Soft Matter Phys |
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Volume |
90 |
Issue |
4 |
Pages |
042710 |
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The ability of migratory birds to orient relative to the Earth's magnetic field is believed to involve a coherent superposition of two spin states of a radical electron pair. However, the mechanism by which this coherence can be maintained in the face of strong interactions with the cellular environment has remained unclear. This paper addresses the problem of decoherence between two electron spins due to hyperfine interaction with a bath of spin-1/2 nuclei. Dynamics of the radical pair density matrix are derived and shown to yield a simple mechanism for sensing magnetic field orientation. Rates of dephasing and decoherence are calculated ab initio and found to yield millisecond coherence times, consistent with behavioral experiments. |
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Max Planck Institute for Physics of Complex Systems, Nothnitzer Strasse 38, D-01187 Dresden, Germany |
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English |
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1539-3755 |
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PMID:25375526 |
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Call Number |
CBM.UAM @ ccobaleda @ |
Serial |
537 |
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Author |
Walleczek, J.; Liburdy, R.P. |
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Title |
Nonthermal 60 Hz sinusoidal magnetic-field exposure enhances 45Ca2+ uptake in rat thymocytes: dependence on mitogen activation |
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Journal Article |
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Year |
1990 |
Publication |
FEBS Letters |
Abbreviated Journal |
FEBS Lett |
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Volume |
271 |
Issue |
1-2 |
Pages |
157-160 |
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Keywords |
Animals; Calcium/*metabolism; Cell Membrane/metabolism; Concanavalin A/*pharmacology; *Electromagnetic Fields; Lymphocyte Activation/*drug effects; Male; Rats; Rats, Inbred Strains; T-Lymphocytes/*metabolism |
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The effect of a 60 Hz sinusoidal magnetic field of nonthermal intensity on Ca2+ metabolism in rat thymic lymphocytes (thymocytes) was assessed in resting cells and in cells activated with the mitogen Concanavalin A (Con A). A 60 min exposure at 37 degrees C to an induced electric field of 1.0 mV/cm produced an average 2.7-fold increase in Con A-dependent 45Ca2(+)-uptake compared to non-exposed, isothermal control cells. In contrast, 45Ca2+ uptake remained unaltered during exposure of resting thymocytes. It was also found that thymocytes with a diminished ability to mobilize Ca2+ in response to Con A were most sensitive to the 60 Hz magnetic field. Although the precise mechanism of field interaction is at present unknown, modulation of Ca2+ metabolism during cell activation may represent a common pathway for field coupling to cellular systems. |
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Research Medicine and Radiation Biophysics Division, Lawrence Berkeley Laboratory, University of California 94720 |
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0014-5793 |
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Notes |
PMID:2226799 |
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IT'IS @ evaj @ |
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428 |
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Author |
Wakeford, R. |
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Title |
The risk of childhood leukaemia following exposure to ionising radiation—a review |
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Journal Article |
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Year |
2013 |
Publication |
Journal of Radiological Protection |
Abbreviated Journal |
J. Radiol. Prot. |
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Volume |
33 |
Issue |
1 |
Pages |
1-25 |
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Abstract |
Since the early years of follow-up of the Japanese atomic-bomb survivors, it has been apparent that childhood leukaemia has a particular sensitivity to induction by ionising radiation, the excess relative risk (ERR) being expressed as a temporal wave with time since exposure. This pattern has been generally confirmed by studies of children treated with radiotherapy. Case-control studies of childhood leukaemia and antenatal exposure to diagnostic x-rays, a recent large cohort study of leukaemia following CT examinations of young people, and a recent large case-control study of natural background γ-radiation and childhood leukaemia have found evidence of raised risks following low-level exposure. These findings indicate that an ERR/Sv for childhood leukaemia of ~50, which may be derived from risk models based upon the Japanese atomic-bomb survivors, is broadly applicable to low dose or low dose-rate exposure circumstances. |
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0952-4746 |
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CBM.UAM @ ccobaleda @ |
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235 |
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