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AyÅŸe, I.-G.; Zafer, A.; Sule, O.; IÅŸil, I.-T.; Kalkan, T. |
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Title |
Differentiation of K562 cells under ELF-EMF applied at different time courses |
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Journal Article |
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Year |
2010 |
Publication |
Electromagnetic biology and medicine |
Abbreviated Journal |
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29 |
Issue |
3 |
Pages |
122-130 |
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Keywords |
Cell Differentiation; Cell Differentiation: drug effects; Cell Differentiation: radiation effects; Electromagnetic Fields; Heat-Shock Response; Heat-Shock Response: drug effects; Heat-Shock Response: radiation effects; Humans; K562 Cells; Magnesium; Magnesium: pharmacology; Reactive Oxygen Species; Reactive Oxygen Species: metabolism; Time Factors |
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The time-course of ELF-EMF application to biological systems is thought to be an important parameter determining the physiological outcome. This study investigated the effect of ELF-EMF on the differentiation of K562 cells at different time courses. ELF-EMF (50 Hz, 5 mT, 1 h) was applied at two different time-courses; first at the onset of hemin induction for 1 h, and second, daily 1 h for four days. While single exposure to ELF-EMF resulted in a decrease in differentiation, ELF-EMF applied everyday for 1 h caused an increase in differentiation. The effect of co-stressors, magnesium, and heat-shock was also determined and similar results were obtained. ELF-EMF increased ROS levels in K562 cells not treated with hemin, however did not change ROS levels of hemin treated cells indicating that ROS was not the cause. Overall, these results imply that the time-course of application is an important parameter determining the physiological response of cells to ELF-EMF. |
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WP5 In vitro |
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UNIBAS @ david.schuermann @ |
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568 |
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Baek, S.; Quan, X.; Kim, S.; Lengner, C.; Park, J.-K.; Kim, J. |
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Title |
Electromagnetic fields mediate efficient cell reprogramming into a pluripotent state |
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Journal Article |
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Year |
2014 |
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ACS nano |
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8 |
Issue |
10 |
Pages |
10125-10138 |
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Keywords |
arth has a magnetic; cell reprogramming; electromagnetic fi elds; epigenetic changes; fi eld that extends; from its inner core; protecting us from a; the solar wind; to where it meets |
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Abstract |
Life on Earth is constantly exposed to natural electromagnetic fields (EMFs), and it is generally accepted that EMFs may exert a variety of effects on biological systems. Particularly, extremely low-frequency electromagnetic fields (EL-EMFs) affect biological processes such as cell development and differentiation; however, the fundamental mechanisms by which EMFs influence these processes remain unclear. Here we show that EMF exposure induces epigenetic changes that promote efficient somatic cell reprogramming to pluripotency. These epigenetic changes resulted from EMF-induced activation of the histone lysine methyltransferase Mll2. Remarkably, an EMF-free system that eliminates Earth's naturally occurring magnetic field abrogates these epigenetic changes, resulting in a failure to undergo reprogramming. Therefore, our results reveal that EMF directly regulates dynamic epigenetic changes through Mll2, providing an efficient tool for epigenetic reprogramming including the acquisition of pluripotency. |
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UNIBAS @ david.schuermann @ |
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546 |
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Bahr, A.; Adami, C.; Bolz, T.; Rennings, A.; Dorn, H.; Ruttiger, L. |
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Exposure setups for laboratory animals and volunteer studies using body-mounted antennas |
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Journal Article |
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2007 |
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Radiation Protection Dosimetry |
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Radiat Prot Dosimetry |
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124 |
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1 |
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31-34 |
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Animals; Body Burden; *Cellular Phone; Computer Simulation; Head/*radiation effects; *Models, Biological; Phantoms, Imaging; Radiation Dosage; Radiometry/instrumentation/*methods; Rats; Volunteers |
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For two different in vivo exposure setups body-mounted antenna systems have been designed. The first setup is designed for investigation of volunteers during simulated mobile phone usage. The setup consists of a dual-band antenna for GSM/WCDMA with enhanced carrying properties, which enables exposure for at least 8 h a day. The 10 g averaged localised SAR--normalised to an antenna input power of 1 W--measured in the flat phantom area of the SAM phantom amounts to 7.82 mW g(-1) (900 MHz) and 10.98 mW g(-1) (1966 MHz). The second exposure setup is used for a laboratory behavioural study on rats. The design goal was a localised, well-defined SAR distribution inside the animals' heads at 900 MHz. To fulfil the biological requirements, a loop antenna was developed. For tissues around the ears, a localised SAR value of 50.12 W kg(-1) averaged over a mass of 2.2 g for an antenna input power of 1 W is obtained. |
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IMST GmbH, Carl-Friedrich-Gauss-Str. 2, D-47475 Kamp-Lintfort, Germany. achim.bahr@imst.de |
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0144-8420 |
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PMID:17595209 |
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CBM.UAM @ ccobaleda @ |
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472 |
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Bakker, J.F.; Paulides, M.M.; Neufeld, E.; Christ, A.; Kuster, N.; van Rhoon, G.C. |
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Children and adults exposed to electromagnetic fields at the ICNIRP reference levels: theoretical assessment of the induced peak temperature increase |
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Journal Article |
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2011 |
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Physics in Medicine and Biology |
Abbreviated Journal |
Phys Med Biol |
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56 |
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15 |
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4967-4989 |
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Adult; Child; Child, Preschool; Electromagnetic Fields/*adverse effects; Environmental Exposure/*adverse effects/*standards; Female; Humans; Male; *Models, Anatomic; Monte Carlo Method; Radiation Dosage; Radiation Protection/*standards; Reference Standards; *Temperature; Uncertainty |
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To avoid potentially adverse health effects of electromagnetic fields (EMF), the International Commission on Non-Ionizing Radiation Protection (ICNIRP) has defined EMF reference levels. Restrictions on induced whole-body-averaged specific absorption rate (SAR(wb)) are provided to keep the whole-body temperature increase (T(body, incr)) under 1 degrees C during 30 min. Additional restrictions on the peak 10 g spatial-averaged SAR (SAR(10g)) are provided to prevent excessive localized tissue heating. The objective of this study is to assess the localized peak temperature increase (T(incr, max)) in children upon exposure at the reference levels. Finite-difference time-domain modeling was used to calculate T(incr, max) in six children and two adults exposed to orthogonal plane-wave configurations. We performed a sensitivity study and Monte Carlo analysis to assess the uncertainty of the results. Considering the uncertainties in the model parameters, we found that a peak temperature increase as high as 1 degrees C can occur for worst-case scenarios at the ICNIRP reference levels. Since the guidelines are deduced from temperature increase, we used T(incr, max) as being a better metric to prevent excessive localized tissue heating instead of localized peak SAR. However, we note that the exposure time should also be considered in future guidelines. Hence, we advise defining limits on T(incr, max) for specified durations of exposure. |
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Erasmus MC-Daniel den Hoed Cancer Center, Department of Radiation Oncology, Section Hyperthermia, PO Box 5201, NL-3008 AE, Rotterdam, The Netherlands. j.bakker@erasmusmc.nl |
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0031-9155 |
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WP2 Exposure measurements |
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PMID:21772085 |
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CNR-ISIB @ paolo.ravazzani @ |
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173 |
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Barbault, A.; Costa, F.P.; Bottger, B.; Munden, R.F.; Bomholt, F.; Kuster, N.; Pasche, B. |
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Amplitude-modulated electromagnetic fields for the treatment of cancer: discovery of tumor-specific frequencies and assessment of a novel therapeutic approach |
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Journal Article |
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2009 |
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Journal of Experimental & Clinical Cancer Research : CR |
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J Exp Clin Cancer Res |
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28 |
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51 |
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Adult; Aged; Aged, 80 and over; Biopsy; *Electromagnetic Fields; Female; Humans; *Magnetic Field Therapy/adverse effects; Male; Middle Aged; Neoplasms/blood/diagnosis/surgery/*therapy; Positron-Emission Tomography; Tomography, X-Ray Computed; Tumor Markers, Biological/blood |
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PURPOSE: Because in vitro studies suggest that low levels of electromagnetic fields may modify cancer cell growth, we hypothesized that systemic delivery of a combination of tumor-specific frequencies may have a therapeutic effect. We undertook this study to identify tumor-specific frequencies and test the feasibility of administering such frequencies to patients with advanced cancer. PATIENTS AND METHODS: We examined patients with various types of cancer using a noninvasive biofeedback method to identify tumor-specific frequencies. We offered compassionate treatment to some patients with advanced cancer and limited therapeutic options. RESULTS: We examined a total of 163 patients with a diagnosis of cancer and identified a total of 1524 frequencies ranging from 0.1 Hz to 114 kHz. Most frequencies (57-92%) were specific for a single tumor type. Compassionate treatment with tumor-specific frequencies was offered to 28 patients. Three patients experienced grade 1 fatigue during or immediately after treatment. There were no NCI grade 2, 3 or 4 toxicities. Thirteen patients were evaluable for response. One patient with hormone-refractory breast cancer metastatic to the adrenal gland and bones had a complete response lasting 11 months. One patient with hormone-refractory breast cancer metastatic to liver and bones had a partial response lasting 13.5 months. Four patients had stable disease lasting for +34.1 months (thyroid cancer metastatic to lung), 5.1 months (non-small cell lung cancer), 4.1 months (pancreatic cancer metastatic to liver) and 4.0 months (leiomyosarcoma metastatic to liver). CONCLUSION: Cancer-related frequencies appear to be tumor-specific and treatment with tumor-specific frequencies is feasible, well tolerated and may have biological efficacy in patients with advanced cancer. TRIAL REGISTRATION: clinicaltrials.gov identifier NCT00805337. |
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Cabinet Medical, Avenue de la Gare 6, Lausanne, Switzerland. alexandre.barbault@gmail.com |
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0392-9078 |
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PMID:19366446 |
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IT'IS @ evaj @ |
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281 |
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