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Author (up) Benfante, R.; Antonini, R.A.; Kuster, N.; Schuderer, J.; Maercker, C.; Adlkofer, F.; Clementi, F.; Fornasari, D. url  doi
openurl 
  Title The expression of PHOX2A, PHOX2B and of their target gene dopamine-beta-hydroxylase (DbetaH) is not modified by exposure to extremely-low-frequency electromagnetic field (ELF-EMF) in a human neuronal model Type Journal Article
  Year 2008 Publication Toxicology in Vitro : an International Journal Published in Association With BIBRA Abbreviated Journal Toxicol In Vitro  
  Volume 22 Issue 6 Pages 1489-1495  
  Keywords Cell Line, Tumor; Dopamine beta-Hydroxylase/radiation effects; Electromagnetic Fields/*adverse effects; Gene Expression/*radiation effects; Homeodomain Proteins/*radiation effects; Humans; Neuroblastoma/metabolism; Time Factors; Transcription Factors/*radiation effects; Transcription, Genetic/radiation effects; Tretinoin/pharmacology  
  Abstract The homeodomain transcription factors PHOX2A and PHOX2B are vital for development of the autonomic nervous system. Their spatial and temporal expression at the neural crest is instrumental in determining neuronal precursor fate, and by regulating DbetaH expression, the enzyme catalysing noradrenaline synthesis from dopamine, they also play a role in determination of noradrenergic phenotype. Disturbing this finely regulated process leads to disruption of autonomic development and autonomic dysfunction syndromes such as DbetaH deficiency. As it had previously been shown that the catecholamine system is responsive to ELF-EMF, and as this has also been linked to various pathologies and to certain types of cancer, we wondered whether exposure to this type of radiation could affect the expression of PHOX2A, PHOX2B and DbetaH, also during differentiation triggered by retinoic acid. To investigate this possibility we exposed the human SH-SY5Y neuroblastoma cell line to 50 Hz power-line magnetic field at various flux densities and for various exposure times. We measured gene expression in exposed cells compared to control cells and also investigated any changes at protein level. Using our exposure protocol, we found no changes at either transcript or protein level of these important components of the autonomic nervous system and catecholaminergic system.  
  Address Department of Pharmacology, School of Medicine, University of Milan, via Vanvitelli 32, Milan, Italy  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0887-2333 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18572378 Approved no  
  Call Number ITIS @ murbach @ Serial 164  
Permanent link to this record
 

 
Author (up) Berg, H. url  doi
openurl 
  Title Bioelectric and Biomagnetic Methods for Cancer Research and Therapy—A Survey Type Journal Article
  Year 2005 Publication Electromagnetic Biology and Medicine Abbreviated Journal Electromagn Biol Med  
  Volume 24 Issue 3 Pages 423-440  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1536-8378 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IT'IS @ evaj @ Serial 288  
Permanent link to this record
 

 
Author (up) Berg, H.; Gunther, B.; Hilger, I.; Radeva, M.; Traitcheva, N.; Wollweber, L. url  doi
openurl 
  Title Bioelectromagnetic field effects on cancer cells and mice tumors Type Journal Article
  Year 2010 Publication Electromagnetic Biology and Medicine Abbreviated Journal Electromagn Biol Med  
  Volume 29 Issue 4 Pages 132-143  
  Keywords Adenocarcinoma/blood supply/pathology/therapy; Animals; Apoptosis/radiation effects; Breast Neoplasms/blood supply/*pathology/*therapy; Electromagnetic Fields/adverse effects; Humans; Hyperthermia, Induced; K562 Cells; Lymphocytes/radiation effects; Magnetic Field Therapy/adverse effects/*methods; Male; Mice; Necrosis; Neovascularization, Pathologic/therapy; *Xenograft Model Antitumor Assays  
  Abstract We present possibilities and trends of ELF bioelectromagnetic effects in the mT amplitude range on cancer cells and on mice bearing tumors. In contrast to invasive electrochemotherapy and electrogenetherapy, using mostly needle electrodes and single high-amplitude electropulses for treatment, extremely low-frequency (ELF) pulsating electromagnetic fields (PEMF) and sinusoidal electromagnetic fields (SEMF) induce tumor cell apoptosis, inhibit angiogenesis, impede proliferation of neoplastic cells, and cause necrosis non invasively, whereas human lymphocytes are negligibly affected. Our successful results in killing cancer cells-analyzed by trypan blue staining or by flow cytometry-and of the inhibition of MX-1 tumors in mice by 15-20 mT, 50 Hz treatment in a solenoid coil also in the presence of bleomycin are presented in comparison to similar experimental results from the literature. In conclusion, the synergistic combinations of PEMF or SEMF with hyperthermia (41.5 degrees C) and/or cancerostatic agents presented in the tables for cells and mice offer a basis for further development of an adjuvant treatment for patients suffering from malignant tumors and metastases pending the near-term development of suitable solenoids of 45-60 cm in diameter, producing >20 mT in their cores.  
  Address Laboratory Bioelectrochemistry, Beutenberg Campus, Jena, Germany  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1536-8386 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21062126 Approved no  
  Call Number IT'IS @ evaj @ Serial 287  
Permanent link to this record
 

 
Author (up) Bernard, N.; Alberdi, A.J.; Tanguy, M.-L.; Brugere, H.; Helissey, P.; Hubert, C.; Gendrey, N.; Guillosson, J.-J.; Nafziger, J. url  openurl
  Title Assessing the potential leukemogenic effects of 50 Hz magnetic fields and their harmonics using an animal leukemia model Type Journal Article
  Year 2008 Publication Journal of Radiation Research Abbreviated Journal J Radiat Res  
  Volume 49 Issue 6 Pages 565-577  
  Keywords Animals; Dose-Response Relationship, Radiation; Electricity; Electromagnetic Fields; Female; Leukemia, Radiation-Induced/*etiology/*physiopathology; Male; Radiation Dosage; Rats; Risk Assessment/*methods; Risk Factors; Whole-Body Irradiation/*methods  
  Abstract To answer the still unresolved question of the possible leukemogenic effects of extremely low frequency magnetic fields (ELF-MFs) and of their harmonics on the incidence of B acute lymphoblastic leukemia in children, we used an animal model to explore the possible co-initiating or co-promoting effects of ELF-MFs on the development of leukemia. We used a rat model in which B acute lymphoblastic leukemia is chemically induced by a nitrosurea derivative. From the onset of the chemical treatment, the animals were also exposed to ELF-MFs (100 microT, sinusoidal 50 Hz MFs), with or without harmonics. The experiment was conducted on 280 rats. We compared body weight and survival time, percentage of bone marrow blast cells, cumulative incidence of leukemia and type of leukemia in the unexposed groups and in the groups exposed to 50 Hz MFs, with and without harmonics. The results showed no significant differences between exposed and unexposed rats for any of these parameters (p > 0.05). Significant changes in the leukemia type obtained after gamma-irradiation of the leukemia model, showed its sensitivity to a physical agent. Our results do not support the hypothesis that ELF-MFs, with or without harmonics, affect the development of B acute lymphoblastic leukemia in children.  
  Address Laboratoire d'Hematologie Cellulaire et Moleculaire, UFR des Sciences Pharmaceutiques et Biologiques, Paris, France  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0449-3060 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18838845 Approved no  
  Call Number CBM.UAM @ ccobaleda @ Serial 476  
Permanent link to this record
 

 
Author (up) Berndt, A.; Kottke, T.; Breitkreuz, H.; Dvorsky, R.; Hennig, S.; Alexander, M.; Wolf, E. url  doi
openurl 
  Title A novel photoreaction mechanism for the circadian blue light photoreceptor Drosophila cryptochrome Type Journal Article
  Year 2007 Publication The Journal of Biological Chemistry Abbreviated Journal J Biol Chem  
  Volume 282 Issue 17 Pages 13011-13021  
  Keywords Animals; Cell Line; *Circadian Rhythm; Cryptochromes; DNA Repair; Deoxyribodipyrimidine Photo-Lyase/chemistry; Drosophila/chemistry/metabolism; Drosophila Proteins/*chemistry/metabolism; Flavin-Adenine Dinucleotide/*chemistry/metabolism; Flavoproteins/*chemistry/metabolism; Oxidation-Reduction; Photochemistry; Photoreceptor Cells, Invertebrate/*chemistry/metabolism  
  Abstract Cryptochromes are flavoproteins that are evolutionary related to the DNA photolyases but lack DNA repair activity. Drosophila cryptochrome (dCRY) is a blue light photoreceptor that is involved in the synchronization of the circadian clock with the environmental light-dark cycle. Until now, spectroscopic and structural studies on this and other animal cryptochromes have largely been hampered by difficulties in their recombinant expression. We have therefore established an expression and purification scheme that enables us to purify mg amounts of monomeric dCRY from Sf21 insect cell cultures. Using UV-visible spectroscopy, mass spectrometry, and reversed phase high pressure liquid chromatography, we show that insect cell-purified dCRY contains flavin adenine dinucleotide in its oxidized state (FAD(ox)) and residual amounts of methenyltetrahydrofolate. Upon blue light irradiation, dCRY undergoes a reversible absorption change, which is assigned to the conversion of FAD(ox) to the red anionic FAD(.) radical. Our findings lead us to propose a novel photoreaction mechanism for dCRY, in which FAD(ox) corresponds to the ground state, whereas the FAD(.) radical represents the light-activated state that mediates resetting of the Drosophila circadian clock.  
  Address Max Planck Institute of Molecular Physiology, Department of Structural Biology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0021-9258 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17298948 Approved no  
  Call Number IT'IS @ evaj @ Serial 255  
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