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Author |
Pui, C.-H.; Relling, M.V.; Downing, J.R. |
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Title |
Acute lymphoblastic leukemia |
Type |
Journal Article |
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Year |
2004 |
Publication |
The New England Journal of Medicine |
Abbreviated Journal |
N Engl J Med |
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Volume |
350 |
Issue |
15 |
Pages |
1535-1548 |
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Keywords |
Age Factors; Genotype; Humans; Molecular Biology; Mutation; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/*genetics; Prognosis; Translocation, Genetic |
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Abstract |
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Address |
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ching-hon.pui@stjude.org |
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English |
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ISSN |
0028-4793 |
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WP6 In vivo |
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Conference |
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Notes |
PMID:15071128 |
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Call Number  |
CBM.UAM @ ccobaleda @ |
Serial |
43 |
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Author |
Pui, C.-H.; Robison, L.L.; Look, A.T. |
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Title |
Acute lymphoblastic leukaemia |
Type |
Journal Article |
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Year |
2008 |
Publication |
Lancet |
Abbreviated Journal |
Lancet |
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Volume |
371 |
Issue |
9617 |
Pages |
1030-1043 |
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Keywords |
Adolescent; Adult; Age Factors; Antineoplastic Agents/*therapeutic use; Child; Child, Preschool; Disease-Free Survival; Humans; Pharmacogenetics; *Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/genetics/physiopathology; Randomized Controlled Trials as Topic; Risk Assessment; Translocation, Genetic/*genetics; Treatment Outcome |
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Abstract |
Acute lymphoblastic leukaemia, a malignant disorder of lymphoid progenitor cells, affects both children and adults, with peak prevalence between the ages of 2 and 5 years. Steady progress in development of effective treatments has led to a cure rate of more than 80% in children, creating opportunities for innovative approaches that would preserve past gains in leukaemia-free survival while reducing the toxic side-effects of current intensive regimens. Advances in our understanding of the pathobiology of acute lymphoblastic leukaemia, fuelled by emerging molecular technologies, suggest that drugs specifically targeting the genetic defects of leukaemic cells could revolutionise management of this disease. Meanwhile, studies are underway to ascertain the precise events that take place in the genesis of acute lymphoblastic leukaemia, to enhance the clinical application of known risk factors and antileukaemic agents, and to identify treatment regimens that might boost the generally low cure rates in adults and subgroups of children with high-risk leukaemia. |
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Address |
Department of Oncology, St Jude Children's Research Hospital and University of Tennessee Health Science Center, Memphis, TN 38105, USA. ching-hon.pui@stjude.org |
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English |
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ISSN |
0140-6736 |
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WP6 In vivo |
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Notes |
PMID:18358930 |
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Call Number |
CBM.UAM @ ccobaleda @ |
Serial |
44 |
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Author |
Schuz, J.; Ahlbom, A. |
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Title |
Exposure to electromagnetic fields and the risk of childhood leukaemia: a review |
Type |
Journal Article |
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Year |
2008 |
Publication |
Radiation Protection Dosimetry |
Abbreviated Journal |
Radiat Prot Dosimetry |
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Volume |
132 |
Issue |
2 |
Pages |
202-211 |
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Keywords |
Body Burden; Child; *Electromagnetic Fields; Environmental Exposure/*statistics & numerical data; Humans; Incidence; Leukemia, Radiation-Induced/*epidemiology; Radiation Monitoring/statistics & numerical data; Risk Assessment/methods; Risk Factors; Young Adult |
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Abstract |
Extremely low-frequency magnetic fields have been classified as possibly carcinogenic to humans, mainly based on epidemiological studies consistently showing an association between long-term average exposures to magnetic fields above 0.3/0.4 microT and the risk of childhood leukaemia. No mechanism to explain this finding has been established and no support for a causal link emerged from experimental studies. Chance or bias cannot be ruled out with reasonable confidence as an explanation for the observed association. If the association is causal, it explains only a small fraction of childhood leukaemia cases. There were some reports of childhood leukaemia clusters in the vicinity of high-power radio and television broadcast transmitters in studies in Australia and Italy. However, recent large-scale systematic studies in Korea and Germany show no association between exposure to radio frequency electromagnetic fields emitted from broadcast towers and childhood leukaemia risk. Studies on mobile phone use and leukaemia risk in adolescents and young adults may be indicated. |
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Address |
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. joachim@cancer.dk |
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English |
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ISSN |
0144-8420 |
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Notes |
PMID:18927133 |
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no |
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Call Number |
CBM.UAM @ ccobaleda @ |
Serial |
45 |
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Author |
Sherborne, A.L.; Hosking, F.J.; Prasad, R.B.; Kumar, R.; Koehler, R.; Vijayakrishnan, J.; Papaemmanuil, E.; Bartram, C.R.; Stanulla, M.; Schrappe, M.; Gast, A.; Dobbins, S.E.; Ma, Y.; Sheridan, E.; Taylor, M.; Kinsey, S.E.; Lightfoot, T.; Roman, E.; Irving, J.A.E.; Allan, J.M.; Moorman, A.V.; Harrison, C.J.; Tomlinson, I.P.; Richards, S.; Zimmermann, M.; Szalai, C.; Semsei, A.F.; Erdelyi, D.J.; Krajinovic, M.; Sinnett, D.; Healy, J.; Gonzalez Neira, A.; Kawamata, N.; Ogawa, S.; Koeffler, H.P.; Hemminki, K.; Greaves, M.; Houlston, R.S. |
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Title |
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk |
Type |
Journal Article |
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Year |
2010 |
Publication |
Nature Genetics |
Abbreviated Journal |
Nat Genet |
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Volume |
42 |
Issue |
6 |
Pages |
492-494 |
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Keywords |
Case-Control Studies; *Chromosomes, Human, Pair 9; *Genes, p16; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics |
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Abstract |
Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage. |
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Address |
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK |
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English |
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Edition |
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ISSN |
1061-4036 |
ISBN |
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Area |
WP6 In vivo |
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Notes |
PMID:20453839 |
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no |
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Call Number |
CBM.UAM @ ccobaleda @ |
Serial |
46 |
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Author |
Steliarova-Foucher, E.; Stiller, C.; Kaatsch, P.; Berrino, F.; Coebergh, J.-W.; Lacour, B.; Parkin, M. |
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Title |
Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCISproject): an epidemiological study |
Type |
Journal Article |
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Year |
2004 |
Publication |
Lancet |
Abbreviated Journal |
Lancet |
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Volume |
364 |
Issue |
9451 |
Pages |
2097-2105 |
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Keywords |
Adolescent; Adult; Age of Onset; Child; Child, Preschool; Europe/epidemiology; Humans; Incidence; Infant; Neoplasms/*epidemiology/mortality; Registries; Survival Rate |
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Abstract |
BACKGROUND: Cancer is rare before age 20 years. We aimed to use the European database of childhood and adolescent cancer cases, within the Automated Childhood Cancer Information System project, to estimate patterns and trends of incidence and survival within Europe. METHODS: Comparable, high-quality data from 63 European population-based cancer registries consisted of 113000 tumours in children and 18243 in adolescents diagnosed in 1970-99. Incidence rates and survival were compared by region (east vs west), period, and malignant disease. FINDINGS: In the 1990s, age-standardised incidence rates were 140 per million for children (0-14 years) and 157 per million for ages 0-19 years. Over the three decades, overall incidence increased by 1.0% per year (p<0.0001) in children (increases for most tumour types), and by 1.5% (p<0.0001) in adolescents (15-19 years; notable increases were recorded for carcinomas, lymphomas, and germ-cell tumours). Overall 5-year survival for children in the 1990s was 64% in the east and 75% in the west, with differences between regions for virtually all tumour groups; 5-year survival was much the same in adolescents. Survival has improved dramatically since the 1970s in children and adolescents, more so in the west than in the east. INTERPRETATION: Our results are clear evidence of an increase of cancer incidence in childhood and adolescence during the past decades, and of an acceleration of this trend. Geographical and temporal patterns suggest areas for further study into causes of these neoplasms, as well as providing an indicator of progress of public-health policy in Europe. |
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Address |
International Agency for Research on Cancer, Lyon, France. steliarova@iarc.fr |
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English |
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Abbreviated Series Title |
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Series Volume |
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ISSN |
0140-6736 |
ISBN |
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Medium |
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Area |
WP9 Epidemiology |
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Notes |
PMID:15589307 |
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Call Number |
CBM.UAM @ ccobaleda @ |
Serial |
47 |
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