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Czyz, J.; Nikolova, T.; Schuderer, J.; Kuster, N.; Wobus, A.M. |
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Title |
Non-thermal effects of power-line magnetic fields (50 Hz) on gene expression levels of pluripotent embryonic stem cells-the role of tumour suppressor p53 |
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Journal Article |
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Year |
2004 |
Publication |
Mutation research |
Abbreviated Journal |
Mutat Res |
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Volume |
557 |
Issue |
1 |
Pages |
63-74 |
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Keywords |
Animals; Cells, Cultured; *Electromagnetic Fields; Embryo, Mammalian/*cytology; Gene Expression Regulation/*radiation effects; Genes, Regulator; Mice; Pluripotent Stem Cells/metabolism/*radiation effects; Tumor Suppressor Protein p53/physiology |
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Abstract |
The diffusion of extremely low-frequency (50 Hz) electromagnetic fields (ELF-EMF) in the human environment raises the question of the induction of biological effects of EMF on mammalian cells. We used the model of mouse pluripotent embryonic stem (ES) cells, which have the capacity to develop in vitro into cells of all lineages, to analyse non-thermal effects of ELF-EMF. Wild type (wt) and p53-deficient ES cells were exposed under controlled conditions to ELF-EMF signals simulating power-line (50 Hz) magnetic field (PL-MF) exposure. Different flux densities of 0.1 mT, 1.0 mT or 2.3 mT and intermittency schemes with various ON/OFF cycles were applied for 6 h or 48 h during the first stages of cell differentiation. Transcript levels of regulatory genes, such as egr-1, p21, c-jun, c-myc, hsp70 and bcl-2, were analysed by semi-quantitative RT-PCR immediately after exposure or after a recovery time of 18 h. Intermittent PL-MF exposure to 5 min ON/30 min OFF cycles at a flux density of 2.3 mT for 6 h resulted in a significant up-regulation of c-jun, p21 and egr-1 mRNA levels in p53-deficient, but not in wild-type cells. No significant effects were observed in both cell systems by PL-MF at lower flux densities, longer exposure time or after 18 h recovery time. Our data indicate that 5 min ON/30 min OFF intermittent PL-MF exposure is capable of evoking non-thermal responses in ES cells, dependent on the cellular p53 function. The nature of the biological responses triggered by PL-MF is discussed. |
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0027-5107 |
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PMID: 14706519 |
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UNIBAS @ david.schuermann @ Czyz2004 |
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73 |
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COEBERGH, J.; REEDIJK, A.; DEVRIES, E.; MARTOS, C.; JAKAB, Z.; STELIAROVAFOUCHER, E.; KAMPS, W. |
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Title |
Leukaemia incidence and survival in children and adolescents in Europe during 1978–1997. Report from the Automated Childhood Cancer Information System project |
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Journal Article |
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Year |
2006 |
Publication |
European Journal of Cancer |
Abbreviated Journal |
European Journal of Cancer |
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42 |
Issue |
13 |
Pages |
2019-2036 |
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0959-8049 |
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WP9 Epidemiology |
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IARC @ ErdmannF @ |
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85 |
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Does, M.; Scélo, G.; Metayer, C.; Selvin, S.; Kavet, R.; Buffler, P. |
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Title |
Exposure to Electrical Contact Currents and the Risk of Childhood Leukemia |
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Journal Article |
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2011 |
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Radiation Research |
Abbreviated Journal |
Radiation Research |
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175 |
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3 |
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390-396 |
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0033-7587 |
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WP9 Epidemiology |
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IARC @ ErdmannF @ |
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86 |
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Draper, G.; Vincent, T.; Kroll, M.E.; Swanson, J. |
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Childhood cancer in relation to distance from high voltage power lines in England and Wales: a case-control study |
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Journal Article |
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2005 |
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BMJ (Clinical Research ed.) |
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BMJ |
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330 |
Issue |
7503 |
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1290 |
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Adolescent; Case-Control Studies; Child; Child, Preschool; Electromagnetic Fields/*adverse effects; England/epidemiology; Environmental Exposure/*adverse effects; Humans; Infant; Infant, Newborn; Neoplasms, Radiation-Induced/epidemiology/*etiology; Residence Characteristics; Risk Factors; Wales/epidemiology |
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OBJECTIVE: To determine whether there is an association between distance of home address at birth from high voltage power lines and the incidence of leukaemia and other cancers in children in England and Wales. DESIGN: Case-control study. SETTING: Cancer registry and National Grid records. SUBJECTS: Records of 29 081 children with cancer, including 9700 with leukaemia. Children were aged 0-14 years and born in England and Wales, 1962-95. Controls were individually matched for sex, approximate date of birth, and birth registration district. No active participation was required. MAIN OUTCOME MEASURES: Distance from home address at birth to the nearest high voltage overhead power line in existence at the time. RESULTS: Compared with those who lived > 600 m from a line at birth, children who lived within 200 m had a relative risk of leukaemia of 1.69 (95% confidence interval 1.13 to 2.53); those born between 200 and 600 m had a relative risk of 1.23 (1.02 to 1.49). There was a significant (P < 0.01) trend in risk in relation to the reciprocal of distance from the line. No excess risk in relation to proximity to lines was found for other childhood cancers. CONCLUSIONS: There is an association between childhood leukaemia and proximity of home address at birth to high voltage power lines, and the apparent risk extends to a greater distance than would have been expected from previous studies. About 4% of children in England and Wales live within 600 m of high voltage lines at birth. If the association is causal, about 1% of childhood leukaemia in England and Wales would be attributable to these lines, though this estimate has considerable statistical uncertainty. There is no accepted biological mechanism to explain the epidemiological results; indeed, the relation may be due to chance or confounding. |
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Childhood Cancer Research Group, University of Oxford, Oxford OX2 6HJ. gerald.draper@ccrg.ox.ac.uk |
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English |
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0959-535X |
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WP9 Epidemiology |
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PMID:15933351 |
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IARC @ ErdmannF @ |
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87 |
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Hodges, E.; Molaro, A.; Dos Santos, C.O.; Thekkat, P.; Song, Q.; Uren, P.J.; Park, J.; Butler, J.; Rafii, S.; McCombie, W.R.; Smith, A.D.; Hannon, G.J. |
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Title |
Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment |
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Journal Article |
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Year |
2011 |
Publication |
Molecular cell |
Abbreviated Journal |
Mol Cell |
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44 |
Issue |
1 |
Pages |
17-28 |
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Abstract |
DNA methylation has been implicated as an epigenetic component of mechanisms that stabilize cell-fate decisions. Here, we have characterized the methylomes of human female hematopoietic stem/progenitor cells (HSPCs) and mature cells from the myeloid and lymphoid lineages. Hypomethylated regions (HMRs) associated with lineage-specific genes were often methylated in the opposing lineage. In HSPCs, these sites tended to show intermediate, complex patterns that resolve to uniformity upon differentiation, by increased or decreased methylation. Promoter HMRs shared across diverse cell types typically display a constitutive core that expands and contracts in a lineage-specific manner to fine-tune the expression of associated genes. Many newly identified intergenic HMRs, both constitutive and lineage specific, were enriched for factor binding sites with an implied role in genome organization and regulation of gene expression, respectively. Overall, our studies represent an important reference data set and provide insights into directional changes in DNA methylation as cells adopt terminal fates. |
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1097-4164 |
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PMID: 21924933 |
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UNIBAS @ david.schuermann @ Hodges2011 |
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75 |
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