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Fadel M. A, R. El-Gebaly, A. Aly, A. Sallam, O. Sarhan and H. Eltohamy |
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Preventing of Ehrlich tumor metastasis in liver, kidney and spleen by electromagnetic field |
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2010 |
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International Journal of the Physical Sciences |
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5 |
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13 |
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2057-2065 |
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Electromagnetic field, liver, kidney, spleen, Ehrlich tumor metastasis, tissue dielectrics |
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The aim of the present work is to study the therapeutic effects of 4.5 Hz of electromagnetic radiation as a preventive agent on the metastasis of Ehrlich tumor which occurred in some organs. The tumor was implanted intramuscularly in the left thigh of mice. Sixty female Balb/c mice were used, twenty as normal group and the other forty were divided equally into 2 groups namely A and B. Group A was the control while group B was whole body exposed to square amplitude modulated waves (QAMW) of frequency 4.5 Hz for a period of 40 h at a rate of 4 h/day starting day 11 post tumor implantation. At the end of the experiment liver, kidney and spleen were excised for all groups. Kidney and spleen were subjected to histological examination. Fragments of the freshly excised liver were subjected to histopathological examination and the other parts were used for dielectric measurements. The results of this work indicate that the treatment of Ehrlich tumor by QAMW caused a decrease in the percentage of metastasis, also there was a decrease in the values of relative permittivity, conductivity and dielectric loss of group B as compared with group A. The statistical methods and analysis for evaluation of the results were done by calculating arithmetic means and standard deviations for percentage of metastasis and dielectric measurements. It may be concluded that whole body exposure of the animals injected with Ehrlich tumor to 4.5 Hz QAMW can inhibit tumor growth in secondary sites or distant organs and can be used as preventive agent to murine metastatic development. |
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IT'IS @ evaj @ |
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453 |
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Mónica Noemà Jiménez-GarcÃa and Juan José Godina-Nava |
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Title |
Possible action mechanism of the electromagnetic fields in the liver cancer development: A mathematical proposal |
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Journal Article |
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2012 |
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AIP Conference Proceedings |
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1420 |
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1 |
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65-70 |
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Electromagnetic Fields, Oxidative Stress, Radical Pairs, Hepatocarcinogenesis |
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ABSTRACT
Currently it is known that electromagnetic field exposure can induce biological changes, although the precise effects and action mechanism of the interaction between the electromagnetic field and biological systems are not well understood. In this work we propose a possible action mechanism, concerning the effect that the extremely low frequency electromagnetic field exposure has on the early stage of liver cancer development. The model is developed studying the phenomena called oxidative stress that it appears after it is applied a carcinogenic agent used to induce hepatic cancer chemically in an experimental animal model. This physical-chemical process involves the movement of magnetic field dependent free charged particles, called free radicals. We will consider the use of the radical pairs theory as a framework, in which we will describe the spin density operator evolution by implementing the stochastic Liouville equation with hyperfine interaction. This describes how the selectivity of the interaction between spin states of the free radicals with the applied electromagnetic field, influences the development of pre-neoplastic lesions in the liver. |
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454 |
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Yan Mi, Chenguo Yao, Chengxiang Li, Kedao Liang, Ruijin Liao, Caixin Sun |
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Development of Steep Pulsed Magnetic Fields Generator for Tumor Treatment |
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2010 |
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Power Modulator and High Voltage Conference (IPMHVC), 2010 IEEE International |
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208-212 |
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In order to study a new tumor treatment method using steep pulsed magnetic fields (SPMF), this paper developed a SPMF generator by means of the integration of pulsed power technology and modern power electronics technology. After a brief introduction of basic principle of SPMF generator, steep pulse formation circuit and Helmholtz coils, two main parts of SPMF generator, were discussed in detail, especially on design techniques. The peak value, width and repeat rate of the output SPMF waveform could be adjusted independently in the range of 0~1 mT, 160 ns~55μs and 1Hz~1 kHz, respectively. The rise time was shortened to 70-220 nanoseconds by means of choosing quickly operating switch and reducing circuit stray inductance. Magnetic field distribution uniformity was improved via designing better geometrical structure of Helmholtz coils. This research laid the foundations for further experiment and mechanism research of tumor treatment utilizing SPMF. |
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455 |
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Yoon, H.E.; Lee, J.S.; Myung, S.H.; Lee, Y.-S. |
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Title |
Increased γ-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines |
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2014 |
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International journal of radiation biology |
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90 |
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4 |
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291-298 |
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Cells; Cultured; DNA Damage; Histones; Histones: metabolism; Humans; Hydrogen Peroxide; Hydrogen Peroxide: pharmacology; Ionizing; Magnetic Fields; Radiation; Sister Chromatid Exchange; Sister Chromatid Exchange: radiation effects |
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PURPOSE: Genotoxic effects have been considered the gold standard to determine if an environmental factor is a carcinogen, but the currently available data for extremely low frequency time-varying magnetic fields (ELF-MF) remain controversial. As an environmental stimulus, the effect of ELF-MF on cellular DNA may be subtle. Therefore, a more sensitive method and systematic research strategy are warranted to evaluate genotoxicity. MATERIALS AND METHODS: We investigated the effect of ELF-MF in combination with ionizing radiation (IR) or H(2)O(2) on the DNA damage response of expression of phosphorylated H2AX (γ-H2AX) and production of γ-H2AX foci in non-tumorigenic human cell systems consisting of human lung fibroblast WI-38 cells and human lung epithelial L132 cells. RESULTS: Exposure to a 60-Hz, 2 mT ELF-MF for 6 h produced increased γ-H2AX expression, as well as γ-H2AX foci production, a common DNA double-strand break (DSB) marker. However, exposure to a 1 mT ELF-MF did not have the same effect. Moreover, 2 mT ELF-MF exposure potentiated the expression of γ-H2AX and γ-H2AX foci production when combined with IR, but not when combined with H(2)O(2). CONCLUSIONS: ELF-MF could affect the DNA damage response and, in combination with different stimuli, provide different effects on γ-H2AX. |
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UNIBAS @ david.schuermann @ |
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545 |
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Baek, S.; Quan, X.; Kim, S.; Lengner, C.; Park, J.-K.; Kim, J. |
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Title |
Electromagnetic fields mediate efficient cell reprogramming into a pluripotent state |
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2014 |
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ACS nano |
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8 |
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10 |
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10125-10138 |
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Keywords |
arth has a magnetic; cell reprogramming; electromagnetic fi elds; epigenetic changes; fi eld that extends; from its inner core; protecting us from a; the solar wind; to where it meets |
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Life on Earth is constantly exposed to natural electromagnetic fields (EMFs), and it is generally accepted that EMFs may exert a variety of effects on biological systems. Particularly, extremely low-frequency electromagnetic fields (EL-EMFs) affect biological processes such as cell development and differentiation; however, the fundamental mechanisms by which EMFs influence these processes remain unclear. Here we show that EMF exposure induces epigenetic changes that promote efficient somatic cell reprogramming to pluripotency. These epigenetic changes resulted from EMF-induced activation of the histone lysine methyltransferase Mll2. Remarkably, an EMF-free system that eliminates Earth's naturally occurring magnetic field abrogates these epigenetic changes, resulting in a failure to undergo reprogramming. Therefore, our results reveal that EMF directly regulates dynamic epigenetic changes through Mll2, providing an efficient tool for epigenetic reprogramming including the acquisition of pluripotency. |
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UNIBAS @ david.schuermann @ |
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546 |
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