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Author |
Barbault, A.; Costa, F.P.; Bottger, B.; Munden, R.F.; Bomholt, F.; Kuster, N.; Pasche, B. |
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Title |
Amplitude-modulated electromagnetic fields for the treatment of cancer: discovery of tumor-specific frequencies and assessment of a novel therapeutic approach |
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Journal Article |
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Year |
2009 |
Publication |
Journal of Experimental & Clinical Cancer Research : CR |
Abbreviated Journal |
J Exp Clin Cancer Res |
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28 |
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51 |
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Keywords |
Adult; Aged; Aged, 80 and over; Biopsy; *Electromagnetic Fields; Female; Humans; *Magnetic Field Therapy/adverse effects; Male; Middle Aged; Neoplasms/blood/diagnosis/surgery/*therapy; Positron-Emission Tomography; Tomography, X-Ray Computed; Tumor Markers, Biological/blood |
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PURPOSE: Because in vitro studies suggest that low levels of electromagnetic fields may modify cancer cell growth, we hypothesized that systemic delivery of a combination of tumor-specific frequencies may have a therapeutic effect. We undertook this study to identify tumor-specific frequencies and test the feasibility of administering such frequencies to patients with advanced cancer. PATIENTS AND METHODS: We examined patients with various types of cancer using a noninvasive biofeedback method to identify tumor-specific frequencies. We offered compassionate treatment to some patients with advanced cancer and limited therapeutic options. RESULTS: We examined a total of 163 patients with a diagnosis of cancer and identified a total of 1524 frequencies ranging from 0.1 Hz to 114 kHz. Most frequencies (57-92%) were specific for a single tumor type. Compassionate treatment with tumor-specific frequencies was offered to 28 patients. Three patients experienced grade 1 fatigue during or immediately after treatment. There were no NCI grade 2, 3 or 4 toxicities. Thirteen patients were evaluable for response. One patient with hormone-refractory breast cancer metastatic to the adrenal gland and bones had a complete response lasting 11 months. One patient with hormone-refractory breast cancer metastatic to liver and bones had a partial response lasting 13.5 months. Four patients had stable disease lasting for +34.1 months (thyroid cancer metastatic to lung), 5.1 months (non-small cell lung cancer), 4.1 months (pancreatic cancer metastatic to liver) and 4.0 months (leiomyosarcoma metastatic to liver). CONCLUSION: Cancer-related frequencies appear to be tumor-specific and treatment with tumor-specific frequencies is feasible, well tolerated and may have biological efficacy in patients with advanced cancer. TRIAL REGISTRATION: clinicaltrials.gov identifier NCT00805337. |
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Cabinet Medical, Avenue de la Gare 6, Lausanne, Switzerland. alexandre.barbault@gmail.com |
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0392-9078 |
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PMID:19366446 |
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IT'IS @ evaj @ |
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281 |
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Cameron, I.L.; Sun, L.-Z.; Short, N.; Hardman, W.E.; Williams, C.D. |
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Title |
Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis |
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Journal Article |
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Year |
2005 |
Publication |
Cancer Cell International |
Abbreviated Journal |
Cancer Cell Int |
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5 |
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23 |
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BACKGROUND: The effects of a rectified semi-sinewave signal (15 mT amplitude, 120 pulses per second, EMF Therapeutics, Inc.) (TEMF) alone and in combination with gamma irradiation (IR) therapy in nude mice bearing a human MDA MB231 breast cancer xenograft were tested. Green fluorescence protein transfected cancer cells were injected into the mammary fat pad of young female mice. Six weeks later, mice were randomly divided into four treatment groups: untreated controls; 10 minute daily TEMF; 200 cGy of IR every other day (total 800 cGy); IR plus daily TEMF. Some mice in each group were euthanized 24 hours after the end of IR. TEMF treatment continued for 3 additional weeks. Tumor sections were stained for: endothelial cells with CD31 and PAS or hypoxia inducible factor 1alpha (HIF). RESULTS: Most tumors <35 mm3 were white but tumors >35 mm3 were pink and had a vascularized capsule. The cortex within 100 microns of the capsule had little vascularization. Blood vessels, capillaries, and endothelial pseudopods were found at >100 microns from the capsule (subcortex). Tumors >35 mm3 treated with IR 24 hours previously or with TEMF had decreased blood vessels in the subcortex and more endothelial pseudopods projecting into hypoxic, HIF positive areas than tumors from the control group. Mice that received either IR or TEMF had significantly fewer lung metastatic sites and slower tumor growth than did untreated mice. No harmful side effects were attributed to TEMF. CONCLUSION: TEMF therapy provided a safe means for retarding tumor vascularization, growth and metastasis. |
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Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78229, USA. cameron@uthscsa.edu |
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1475-2867 |
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PMID:16045802 |
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IT'IS @ evaj @ |
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289 |
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Gluck, B.; Guntzschel, V.; Berg, H. |
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Title |
Inhibition of proliferation of human lymphoma cells U937 by a 50 Hz electromagnetic field |
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Journal Article |
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Year |
2001 |
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Cellular and Molecular Biology (Noisy-le-Grand, France) |
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Cell Mol Biol (Noisy-le-Grand) |
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47 Online Pub |
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Ol115-7 |
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Apoptosis; *Cell Division; *Electromagnetic Fields; Humans; Time Factors; U937 Cells |
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Weak pulsating electromagnetically induced fields (PEMF) by Helmholtz coils changes cell metabolism, if cells are treated with a certain range of frequency and amplitude. The influence on proliferation of human histiocytic lymphoma cells U937 has been studied applying a sinusoidal 50 Hz field with amplitudes of the flux density B = 0.3 to 4.7 mT for 4 days. No difference between experiment and control was found in the region 0.3 and 2 mT. However, stronger fields (> or =2.5 mT) inhibit cell division. Fields > or =3.5 mT treatment kill > or =80% of the cell number at the beginning (1.5 x 10(5)/ml). This effect may be an electromagnetocally induced cell death as the first step for a non-invasive application on cell proliferation process. |
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Laboratory Cell Culture, Institute of Virology, Friedrich-Schiller-University Jena, Germany. i6glbr@rz.uni-jena.de |
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0145-5680 |
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PMID:11936855 |
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IT'IS @ evaj @ |
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309 |
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Lai, H.C.; Singh, N.P. |
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Title |
Medical applications of electromagnetic fields |
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Journal Article |
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2010 |
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IOP Conference Series: Earth and Environmental Science |
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IOP Conf. Ser.: Earth Environ. Sci. |
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10 |
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012006 |
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1755-1315 |
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IT'IS @ evaj @ |
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340 |
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Mi, Y.; Sun, C.; Yao, C.; Xiong, L.; Wang, S.; Li, C.; Li, J.; Hu, L. |
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Title |
Lethal Effects of Steep Pulsed Electric Field (SPEF) to Target Lymphatic Capillaries in VX<inf>2</inf>Implanted Breast Cancer of Rabbits |
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Journal Article |
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Year |
2005 |
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Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference |
Abbreviated Journal |
Conf Proc IEEE Eng Med Biol Soc |
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5 |
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4904-4907 |
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This paper discussed the lethal effects of Steep Pulsed Electric Field (SPEF) to target lymphatic capillaries in VX<inf>2</inf>implanted breast cancer of rabbits using methylene blue dye injection staining, 5'-AMP-ALPase enzyme histochemical double staining, electron microscopy and VEGF-C observations. The result of methylene blue dye perfusion showed that the edge of tumor treated with SPEF was indistinct, no circularity or liner structure. Enzyme histochemical staining examination displayed that no positive staining was found in SPEF-target region of breast tumor, and lymphatic capillaries presented piecemeal structure in the edge of target region. Transmission electron microscopic examination showed that the continuity and integrality of lymphatic capillaries in tumor were destroyed after the treatment of SPEF. The expression of VEGF-C decreased markedly. The experiment indicated that SPEF induced the severe destruction of tumor cell and lymphatic capillaries in target region, and inhibited proliferation of lymphatic. Therefore it can decrease the possibility of lymphatic metastasis. |
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Key Lab of High Voltage Engineering and Electrical New Technology, Ministry of Education, Chongqing University, Chongqing, 400044 P. R. China (Phone: 86-23-65111172-8307; fax: 86-23-65106818; e-mail: miyan@cqu.edu.cn) |
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1557-170X |
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PMID:17281342 |
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IT'IS @ evaj @ |
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355 |
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