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Author Focke, F.; Schuermann, D.; Kuster, N.; Schär, P. url  doi
openurl 
  Title DNA fragmentation in human fibroblasts under extremely low frequency electromagnetic field exposure Type Journal Article
  Year 2010 Publication Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Abbreviated Journal Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis  
  Volume 683 Issue 1-2 Pages 74-83  
  Keywords (up)  
  Abstract Extremely low frequency electromagnetic fields (ELF-EMFs) were reported to affect DNA integrity in human cells with evidence based on the Comet assay. These findings were heavily debated for two main reasons; the lack of reproducibility, and the absence of a plausible scientific rationale for how EMFs could damage DNA. Starting out from a replication of the relevant experiments, we performed this study to clarify the existence and explore origin and nature of ELF-EMF induced DNA effects. Our data confirm that intermittent (but not continuous) exposure of human primary fibroblasts to a 50 Hz EMF at a flux density of 1 mT induces a slight but significant increase of DNA fragmentation in the Comet assay, and we provide first evidence for this to be caused by the magnetic rather than the electric field. Moreover, we show that EMF-induced responses in the Comet assay are dependent on cell proliferation, suggesting that processes of DNA replication rather than the DNA itself may be affected. Consistently, the Comet effects correlated with a reduction of actively replicating cells and a concomitant increase of apoptotic cells in exposed cultures, whereas a combined Fpg-Comet test failed to produce evidence for a notable contribution of oxidative DNA base damage. Hence, ELF-EMF induced effects in the Comet assay are reproducible under specific conditions and can be explained by minor disturbances in S-phase processes and occasional triggering of apoptosis rather than by the generation of DNA damage.  
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  ISSN 0027-5107 ISBN Medium  
  Area WP5 In vitro Expedition Conference  
  Notes PMID: 19896957 Approved no  
  Call Number IT'IS @ kuster @ Serial 23  
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Author Wolf, C. url  doi
openurl 
  Title Security considerations in blinded exposure experiments using electromagnetic waves Type Journal Article
  Year 2008 Publication Bioelectromagnetics Abbreviated Journal Bioelectromagnetics  
  Volume 29 Issue 8 Pages 658-659  
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  ISSN 0197-8462 ISBN Medium  
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  Notes Approved no  
  Call Number IT'IS @ kuster @ Serial 24  
Permanent link to this record
 
 
Author Kuster, N.; Schönborn, F. url  doi
openurl 
  Title Recommended minimal requirements and development guidelines for exposure setups of bio-experiments addressing the health risk concern of wireless communications Type Journal Article
  Year 2000 Publication Bioelectromagnetics Abbreviated Journal Bioelectromagnetics  
  Volume 21 Issue 7 Pages 508-514  
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  ISSN 0197-8462 ISBN Medium  
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  Notes Approved no  
  Call Number IT'IS @ kuster @ Serial 26  
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Author Kuster, N.; Torres, V.B.; Nikoloski, N.; Frauscher, M.; Kainz, W. url  doi
openurl 
  Title Methodology of detailed dosimetry and treatment of uncertainty and variations for in vivo studies Type Journal Article
  Year 2006 Publication Bioelectromagnetics Abbreviated Journal Bioelectromagnetics  
  Volume 27 Issue 5 Pages 378-391  
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  ISSN 0197-8462 ISBN Medium  
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  Notes Approved no  
  Call Number IT'IS @ kuster @ Serial 27  
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Author Kuster, N. openurl 
  Title Increasing Bias towards False Negative Replications? Type Journal Article
  Year 2011 Publication BEMS NEWSLETTER, www.bems.org Abbreviated Journal  
  Volume Issue 217 Pages 1-5  
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  Area WP9 Epidemiology Expedition Conference  
  Notes ian Approved no  
  Call Number IT'IS @ kuster @ Kuster:2011tt Serial 20  
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