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Duan, Y.; Wang, Z.; Zhang, H.; He, Y.; Fan, R.; Cheng, Y.; Sun, G.; Sun, X. |
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Title |
Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod |
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Journal Article |
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Year |
2014 |
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Food & Function |
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5 |
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2289-2289 |
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Royal Society of Chemistry |
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WP5 In vitro |
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UNIBAS @ david.schuermann @ |
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616 |
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Author |
Fedele, G.; Edwards, M.D.; Bhutani, S.; Hares, J.M.; Murbach, M.; Green, E.W.; Dissel, S.; Hastings, M.H.; Rosato, E.; Kyriacou, C.P. |
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Title |
Genetic Analysis of Circadian Responses to Low Frequency Electromagnetic Fields in <italic>Drosophila melanogaster</italic> |
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Journal Article |
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Year |
2014 |
Publication |
PLoS Genet |
Abbreviated Journal |
PLoS Genet |
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Volume |
10 |
Issue |
12 |
Pages |
e1004804EP - |
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<title>Author Summary</title> <p>Low frequency electromagnetic fields (EMFs) are associated with electrical power lines and have been implicated in the development of childhood leukemias. However, the Earth also has a natural EMF that animals can detect and which they use in order to navigate and orient themselves, particularly during migrations. One way they might do this is by using specialised photoreceptors called cryptochromes, which when activated by light, generate changes within the molecule that are susceptible to EMFs. Cryptochromes are important components of animal circadian clocks, the 24 hour timers that determine daily behavioral and physiological cycles. We have studied the circadian behavior of the fruitfly and have observed some novel and robust effects of EMFs on the fly's sleep-wake cycle that are mediated by cryptochrome. By using cryptochrome mutants we find that our results do not support the classic model for how this molecule might respond to EMFs. We also show that mammalian cryptochromes can respond to EMF when placed into transgenic Drosophila, whereas in mammalian clock neurons, they cannot. Consequently, the EMF responsiveness of cryptochrome is determined by its intracellular environment, suggesting that other, unknown molecules that interact with cryptochrome are also very important.</p> |
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Public Library of Science |
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WP5 In vitro; WP6 In vivo |
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UNIBAS @ david.schuermann @ |
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635 |
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Fedele, G.; Green, E.W.; Rosato, E.; Kyriacou, C.P. |
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Title |
An electromagnetic field disrupts negative geotaxis in Drosophila via a CRY-dependent pathway |
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Journal Article |
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Year |
2014 |
Publication |
Nature communications |
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5 |
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4391-4391 |
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Many higher animals have evolved the ability to use the Earth's magnetic field, particularly for orientation. Drosophila melanogaster also respond to electromagnetic fields (EMFs), although the reported effects are quite modest. Here we report that negative geotaxis in flies, scored as climbing, is disrupted by a static EMF, and this is mediated by cryptochrome (CRY), the blue-light circadian photoreceptor. CRYs may sense EMFs via formation of radical pairs of electrons requiring photoactivation of flavin adenine dinucleotide (FAD) bound near a triad of Trp residues, but mutation of the terminal Trp in the triad maintains EMF responsiveness in climbing. In contrast, deletion of the CRY C terminus disrupts EMF responses, indicating that it plays an important signalling role. CRY expression in a subset of clock neurons, or the photoreceptors, or the antennae, is sufficient to mediate negative geotaxis and EMF sensitivity. Climbing therefore provides a robust and reliable phenotype for studying EMF responses in Drosophila. |
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Nature Publishing Group |
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WP6 In vivo; WP5 In vitro |
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UNIBAS @ david.schuermann @ |
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551 |
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Author |
Marley, R.; Giachello, C.N.G.; Scrutton, N.S.; Baines, R.A.; Jones, A.R. |
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Title |
Cryptochrome-dependent magnetic field effect on seizure response in Drosophila larvae |
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Journal Article |
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Year |
2014 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
4 |
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Pages |
5799 |
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The mechanisms that facilitate animal magnetoreception have both fascinated and confounded scientists for decades, and its precise biophysical origin remains unclear. Among the proposed primary magnetic sensors is the flavoprotein, cryptochrome, which is thought to provide geomagnetic information via a quantum effect in a light-initiated radical pair reaction. Despite recent advances in the radical pair model of magnetoreception from theoretical, molecular and animal behaviour studies, very little is known of a possible signal transduction mechanism. We report a substantial effect of magnetic field exposure on seizure response in Drosophila larvae. The effect is dependent on cryptochrome, the presence and wavelength of light and is blocked by prior ingestion of typical antiepileptic drugs. These data are consistent with a magnetically-sensitive, photochemical radical pair reaction in cryptochrome that alters levels of neuronal excitation, and represent a vital step forward in our understanding of the signal transduction mechanism involved in animal magnetoreception. |
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Nature Publishing Group |
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2045-2322 |
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WP5 In vitro; WP6 In vivo |
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no |
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UNIBAS @ david.schuermann @ |
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636 |
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Author |
Barteri, M.; De Carolis, R.; Marinelli, F.; Tomassetti, G.; Montemiglio, L.C. |
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Title |
Effects of microwaves (900 MHz) on peroxidase systems: a comparison between lactoperoxidase and horseradish peroxidase |
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Journal Article |
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Year |
2015 |
Publication |
Electromagnetic Biology and Medicine |
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Volume |
00 |
Issue |
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Pages |
1-7 |
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Keywords |
900 mhz; 900 MHz; electromagneti fields; enzyme kinetics; horseradish peroxidase; lactoperoxidase; microwaves; radiofrequency; peroxidase; enzyme; kinetics |
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Informa Healthcare USA, Inc |
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UNIBAS @ david.schuermann @ |
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630 |
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