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Author |
Mert, T.; Ocal, I.; Cinar, E.; Yalcin, M.S.; Gunay, I. |
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Title |
Pain-relieving effects of pulsed magnetic fields in a rat model of carrageenan-induced hindpaw inflammation |
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Journal Article |
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Year |
2014 |
Publication |
International Journal of Radiation Biology |
Abbreviated Journal |
Int J Radiat Biol |
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Volume |
90 |
Issue |
1 |
Pages |
95-103 |
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Keywords |
Animals; Carrageenan; Disease Models, Animal; Female; Humans; Hyperalgesia/chemically induced/*prevention & control; Inflammation/chemically induced/*prevention & control; Magnetic Field Therapy/*methods; Rats; Rats, Wistar; Treatment Outcome |
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Abstract |
PURPOSE: Many strategies have been investigated to exclude the several side-effects of pharmacological or invasive treatments. Non-invasive pulsed magnetic field (PMF) treatment with no toxicity or side-effects can be an alternative to pharmacologic treatments. The purpose of this study was, therefore, to investigate the pain-relieving effects of PMF treatment in the inflammatory pain conditions. MATERIALS AND METHODS: Effects of PMF treatment on the hallmarks of the inflammatory pain indices such as hyperalgesia, allodynia, edema and several biochemical parameters that evaluate oxidative stress were investigated using a well established carrageenan (CAR)-induced hindpaw inflammation model in rats. RESULTS: CAR injection lowered the paw withdrawal thermal latencies (hyperalgesia) and mechanical thresholds (allodynia). CAR also decreased the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels and increased malondialdehyde (MDA) levels compared with healthy rat paw tissues. PMF treatment produced significant increases in the thermal latencies and mechanical thresholds in CAR-injected paws. In the inflamed paw tissues, PMF increased the activities of SOD, CAT and GPx and decreased MDA level. We also demonstrated that PMF decreased paw mass indicating that it has an anti-edematous potential. CONCLUSIONS: The present results reveal that PMF treatment can ameliorate the CAR-induced inflammatory pain indices such as mechanical allodynia, thermal hyperalgesia and edema, and attenuate the oxidative stress. The action mechanisms of PMF in CAR-induced inflammation might be related to the increases in the levels of antioxidant enzymes in inflamed tissues. The findings suggest that PMF treatment might be beneficial in inflammatory pain conditions. |
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Department of Biophysics, School of Medicine, Kahramanmaras Sutcu Imam University , Kahramanmaras |
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ISSN |
0955-3002 |
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PMID:23952340 |
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CBM.UAM @ ccobaleda @ |
Serial  |
598 |
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Author |
Manikonda, P.K.; Rajendra, P.; Devendranath, D.; Gunasekaran, B.; Channakeshava; Aradhya, S.R.S.; Sashidhar, R.B.; Subramanyam, C. |
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Title |
Extremely low frequency magnetic fields induce oxidative stress in rat brain |
Type |
Journal Article |
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Year |
2014 |
Publication |
General Physiology and Biophysics |
Abbreviated Journal |
Gen Physiol Biophys |
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Volume |
33 |
Issue |
1 |
Pages |
81-90 |
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Keywords |
Animals; Antioxidants/chemistry/metabolism; Brain/*pathology; Brain Mapping/methods; Cerebellum/metabolism; Cerebral Cortex/metabolism; Glutathione/chemistry/metabolism; Hippocampus/metabolism; *Lipid Peroxidation; *Magnetic Fields; Male; *Oxidative Stress; Rats; Rats, Wistar; *Reactive Oxygen Species; Superoxide Dismutase/metabolism |
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Abstract |
The present investigation was conducted to understand the influence of long-term exposure of rats to extremely low frequency magnetic fields (ELF-MF), focusing on oxidative stress (OS) on different regions of rat's brain. Male Wistar rats (21-day-old) were exposed to ELF-MF (50 Hz; 50 and 100 microT) for 90 days continuously; hippocampal, cerebellar and cortical regions from rats were analyzed for (i) reactive oxygen species (ROS), (ii) metabolites indicative of OS and (iii) antioxidant enzymes. In comparison to control group rats, the rats that were continuously exposed to ELF-MF caused OS and altered glutathione (GSH/GSSG) levels in dose-dependent manner in all the regions of the brain. Accumulation of ROS, lipid peroxidation end products and activity of superoxide dismutase in different regions was in the descending order of cerebellum < hippocampus < cortex. Decrement in GSH/GSSG levels and increment in glutathione peroxidase activity were in the descending order of hippocampus < cerebellum < cortex. The continuous exposure to ELF-MF caused OS in all the examined regions of brain more significantly at 100 microT than at 50 microT. Varied influences observed in different regions of the brain, as documented in this study, may contribute to altered metabolic patterns in its related regions of the central nervous system, leading to aberrant neuronal functions. |
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Department of Biochemistry, University College of Science, Osmania University, Hyderabad-500 007, AP, India. sashi_rao@yahoo.com |
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0231-5882 |
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PMID:24334533 |
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CBM.UAM @ ccobaleda @ |
Serial |
597 |
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Author |
Mahna, A.; Firoozabadi, S.M.P.; Shankayi, Z. |
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Title |
The effect of ELF magnetic field on tumor growth after electrochemotherapy |
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Journal Article |
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Year |
2014 |
Publication |
The Journal of Membrane Biology |
Abbreviated Journal |
J Membr Biol |
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Volume |
247 |
Issue |
1 |
Pages |
9-15 |
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Keywords |
Animals; Antibiotics, Antineoplastic/administration & dosage/toxicity; Bleomycin/administration & dosage/toxicity; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; *Electrochemotherapy; *Electromagnetic Fields; Mice; Neoplasms/*pathology/*therapy; Tumor Burden/drug effects/radiation effects |
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Abstract |
From a fundamental point of view, chemotherapy is the most widely used treatment for cancers despite its side effects on normal cells and tissues. Electrochemotherapy (ECT) is a method for increasing the permeability of cancer cells to drugs and, hence, decreasing their dosage. It apparently creates electropores on the cell membrane using electric pulses. ECT can decrease tumor volume; but this effect is not permanent, and partial regrowth has been reported. The aim of this study was to investigate the potential of magnetic fields in preventing the regrowth of tumors after ECT. Tumoral Balb/c mice were exposed to a magnetic field (15 mT, 50 Hz) for 12 days after treating additionally with 70 V/cm electric pulses and bleomycin at the first day. The magnetic field caused a significant reduction in tumor volumes, while there was no significant difference between the ECT and the electroporation with ECT and magnetic field groups. The exploited magnetic field (15 mT, 50 Hz) could decrease the tumor growth rate significantly, without any effect on ECT efficiency. |
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Department of Medical Physics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran |
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ISSN |
0022-2631 |
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PMID:24186355 |
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CBM.UAM @ ccobaleda @ |
Serial |
596 |
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Author |
Li, Y.; Zhang, C.; Song, T. |
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Title |
Disturbance of the magnetic field did not affect spatial memory |
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Journal Article |
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Year |
2014 |
Publication |
Physiological Research / Academia Scientiarum Bohemoslovaca |
Abbreviated Journal |
Physiol Res |
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Volume |
63 |
Issue |
3 |
Pages |
377-385 |
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Abstract |
Extremely low-frequency magnetic field (ELF-MF) has been suggested to influence the cognitive capability but this should be dynamically evaluated in a longitudinal study. Previous training can affect performance, but the influence under magnetic field is unclear. This study aims to evaluate the effects of previous training and ELF-MF exposure on learning and memory using the Morris water maze (MWM). Sprague-Dawley rats were subjected to MWM training, ELF-MF exposure (50 Hz, 100 microT), or ELF-MF exposure combined with MWM training for 90 days. Normal rats were used as controls. The MWM was used to test. The data show that the rats exposed to training and ELF-MF with training performed better on spatial acquisition when re-tested. However, during the probe trial the rats showed no change between the training phase and the test phase. Compared with the control group, the ELF-MF group showed no significant differences. These results confirm that previous training can improve the learning and memory capabilities regarding spatial acquisition in the MWM and this effect can last for at least 90 days. However, this improvement in learning and memory capabilities was not observed during the probe trial. Furthermore, ELF-MF exposure did not interfere with the improvement in learning and memory capabilities. |
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Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, China. songtao@mail.iee.ac.cn |
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ISSN |
0862-8408 |
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PMID:24564597 |
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CBM.UAM @ ccobaleda @ |
Serial |
595 |
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Author |
Li, C.; Xie, M.; Luo, F.; He, C.; Wang, J.; Tan, G.; Hu, Z. |
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Title |
The extremely low-frequency magnetic field exposure differently affects the AMPAR and NMDAR subunit expressions in the hippocampus, entorhinal cortex and prefrontal cortex without effects on the rat spatial learning and memory |
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Journal Article |
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Year |
2014 |
Publication |
Environmental Research |
Abbreviated Journal |
Environ Res |
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Volume |
134 |
Issue |
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74-80 |
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Keywords |
Animals; Entorhinal Cortex/*metabolism; Hippocampus/*metabolism; *Magnetic Fields; Male; Memory; Prefrontal Cortex/*metabolism; Rats; Rats, Sprague-Dawley; Receptors, AMPA/*metabolism; Receptors, N-Methyl-D-Aspartate/*metabolism; Spatial Learning; AMPARs; Entorhinal cortex; Extremely low frequency magnetic field; Learning and memory; NMDARs |
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In the present study, we investigated the effects of chronic exposure (14 and 28 days) to a 50 Hz, 0.5 mT extremely low-frequency magnetic field (ELF-MF) on the NMDAR and AMPAR subunit expressions and rat spatial learning and memory. Using the Western blotting method, we found ELF-MF exposure specifically decreased the expressions of GluA2 in the EC post 28 day exposure and GluA3 of AMPAR subunits in the PFC after 14 day exposure, while it did not affect the AMPAR subunit expression in the hippocampus at both time points. As for NMDAR subunits, 14 day ELF-MF exposure significantly increased the levels of GluN2A and GluN2B in the hippocampus. Moreover, the levels of GluN1 and GluN2A were enhanced in the EC and PFC after two weeks of ELF-MF exposure. Interestingly, 28 day ELF-MF exposure induced a different expression pattern for NMDAR subunits. The increased GluN2A expression observed at 14 day post ELF-MF exposure was recovered after prolonged exposure in the hippocampus and PFC. In the EC, the increased expression of GluN1 achieved to control level and, specifically, a decrease in GluN2A level was observed. Surprisingly, neither 14 nor 28 day ELF-MF did affect the rat spatial reference memory as assessed by water maze. These results indicate that the dynamic and brain-region specific changes in ionotropic glutamate receptor expression induced by ELF-MF are insufficient to influence the rat spatial learning ability. |
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Department of Physiology, Third Military Medical University, Chongqing 400038, PR China. Electronic address: zhianhu@aliyun.com |
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0013-9351 |
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PMID:25046815 |
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CBM.UAM @ ccobaleda @ |
Serial |
594 |
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