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| Author | Duan, Y.; Wang, Z.; Zhang, H.; He, Y.; Fan, R.; Cheng, Y.; Sun, G.; Sun, X. | ||||
| Title | Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod | Type | Journal Article | ||
| Year | 2014 | Publication | Food & Function | Abbreviated Journal | |
| Volume | 5 | Issue | Pages | 2289-2289 | |
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| Publisher | Royal Society of Chemistry | Place of Publication | Editor | ||
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| Area | WP5 In vitro | Expedition | Conference | ||
| Notes | Approved | no | |||
| Call Number | UNIBAS @ david.schuermann @ | Serial | 616 | ||
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| Author | Winklhofer, M. | ||||
| Title | An Avian Magnetometer | Type | Journal Article | ||
| Year | 2012 | Publication | Science | Abbreviated Journal | Science |
| Volume | 336 | Issue | 6084 | Pages | 991-992 |
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| Abstract | Homing pigeons have remarkable navigational
skills that allow them to fi nd their way back to the loft when released from an unfamiliar location hundreds of miles away. To perform such a feat, they rely on various cues, such as odors and Earth’s magnetic fi eld ( 1, 2). Yet, how birds and other animals obtain magnetic-fi eld information has been a mystery. On page 1054 of this issue, Wu and Dickman ( 3) report how this information is neurally encoded and suggest a candidate magnetic sensory organ in the inner ear of the pigeon ( 4). |
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| ISSN | 0036-8075 | ISBN | Medium | ||
| Area | WP6 In vivo | Expedition | Conference | ||
| Notes | Approved | no | |||
| Call Number | CBM.UAM @ ccobaleda @ | Serial | 188 | ||
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| Author | Hirota, T.; Lee, J.W.; St. John, P.C.; Sawa, M.; Iwaisako, K.; Noguchi, T.; Pongsawakul, P.Y.; Sonntag, T.; Welsh, D.K.; Brenner, D.A.; Doyle, F.J.; Schultz, P.G.; Kay, S.A. | ||||
| Title | Identification of Small Molecule Activators of Cryptochrome | Type | Journal Article | ||
| Year | 2012 | Publication | Science | Abbreviated Journal | Science |
| Volume | 337 | Issue | 6098 | Pages | 1094-1097 |
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| ISSN | 0036-8075 | ISBN | Medium | ||
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| Notes | Approved | no | |||
| Call Number | IT'IS @ evaj @ | Serial | 449 | ||
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| Author | Lu, Y.; He, M.; Zhang, Y.; Xu, S.; Zhang, L.; He, Y.; Chen, C.; Liu, C.; Pi, H.; Yu, Z.; Zhou, Z. | ||||
| Title | Differential Pro-Inflammatory Responses of Astrocytes and Microglia Involve STAT3 Activation in Response to 1800 MHz Radiofrequency Fields | Type | Journal Article | ||
| Year | 2014 | Publication | PloS one | Abbreviated Journal | |
| Volume | 9 | Issue | 9 | Pages | e108318-e108318 |
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| Abstract | Microglia and astrocytes play important role in maintaining the homeostasis of central nervous system (CNS). Several CNS impacts have been postulated to be associated with radiofrequency (RF) electromagnetic fields exposure. Given the important role of inflammation in neural physiopathologic processes, we investigated the pro-inflammatory responses of microglia and astrocytes and the involved mechanism in response to RF fields. Microglial N9 and astroglial C8-D1A cells were exposed to 1800 MHz RF for different time with or without pretreatment with STAT3 inhibitor. Microglia and astrocytes were activated by RF exposure indicated by up-regulated CD11b and glial fibrillary acidic protein (GFAP). However, RF exposure induced differential pro-inflammatory responses in astrocytes and microglia, characterized by different expression and release profiles of IL-1β, TNF-α, IL-6, PGE2, nitric oxide (NO), inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2). Moreover, the RF exposure activated STAT3 in microglia but not in astrocytes. Furthermore, the STAT3 inhibitor Stattic ameliorated the RF-induced release of pro-inflammatory cytokines in microglia but not in astrocytes. Our results demonstrated that RF exposure differentially induced pro-inflammatory responses in microglia and astrocytes, which involved differential activation of STAT3 in microglia and astrocytes. Our data provide novel insights into the potential mechanisms of the reported CNS impacts associated with mobile phone use and present STAT3 as a promising target to protect humans against increasing RF exposure. | ||||
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| Notes | Approved | no | |||
| Call Number | UNIBAS @ david.schuermann @ | Serial | 555 | ||
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| Author | Reale, M.; Kamal, M. a; Patruno, A.; Costantini, E.; D'Angelo, C.; Pesce, M.; Greig, N.H. | ||||
| Title | Neuronal cellular responses to extremely low frequency electromagnetic field exposure: implications regarding oxidative stress and neurodegeneration | Type | Journal Article | ||
| Year | 2014 | Publication | PloS one | Abbreviated Journal | |
| Volume | 9 | Issue | 8 | Pages | e104973-e104973 |
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| Abstract | Neurodegenerative diseases comprise both hereditary and sporadic conditions characterized by an identifying progressive nervous system dysfunction and distinctive neuopathophysiology. The majority are of non-familial etiology and hence environmental factors and lifestyle play key roles in their pathogenesis. The extensive use of and ever increasing worldwide demand for electricity has stimulated societal and scientific interest on the environmental exposure to low frequency electromagnetic fields (EMFs) on human health. Epidemiological studies suggest a positive association between 50/60-Hz power transmission fields and leukemia or lymphoma development. Consequent to the association between EMFs and induction of oxidative stress, concerns relating to development of neurodegenerative diseases, such as Alzheimer disease (AD), have been voiced as the brain consumes the greatest fraction of oxygen and is particularly vulnerable to oxidative stress. Exposure to extremely low frequency (ELF)-EMFs are reported to alter animal behavior and modulate biological variables, including gene expression, regulation of cell survival, promotion of cellular differentiation, and changes in cerebral blood flow in aged AD transgenic mice. Alterations in inflammatory responses have also been reported, but how these actions impact human health remains unknown. We hence evaluated the effects of an electromagnetic wave (magnetic field intensity 1mT; frequency, 50-Hz) on a well-characterized immortalized neuronal cell model, human SH-SY5Y cells. ELF-EMF exposure elevated the expession of NOS and O2-, which were countered by compensatory changes in antioxidant catylase (CAT) activity and enzymatic kinetic parameters related to CYP-450 and CAT activity. Actions of ELF-EMFs on cytokine gene expression were additionally evaluated and found rapidly modified. Confronted with co-exposure to H2O2-induced oxidative stress, ELF-EMF proved not as well counteracted and resulted in a decline in CAT activity and a rise in O2- levels. Together these studies support the further evaluation of ELF-EMF exposure in cellular and in vivo preclinical models to define mechanisms potentially impacted in humans. | ||||
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| Notes | Approved | no | |||
| Call Number | UNIBAS @ david.schuermann @ | Serial | 625 | ||
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