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Author |
Nindl, G.; Swez, J.A.; Miller, J.M.; Balcavage, W.X. |
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Title |
Growth stage dependent effects of electromagnetic fields on DNA synthesis of Jurkat cells |
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Journal Article |
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Year |
1997 |
Publication |
FEBS Letters |
Abbreviated Journal |
FEBS Lett |
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Volume |
414 |
Issue |
3 |
Pages |
501-506 |
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Keywords |
Cell Division; DNA/*biosynthesis; *Electromagnetic Fields; Humans; Jurkat Cells/*cytology/*physiology; Receptors, Antigen, T-Cell/metabolism; Thymidine/metabolism/pharmacokinetics |
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Abstract |
A 1.8 mT, bone healing, electromagnetic field (EMF) and power frequency EMFs of 0.1 and 0.4 mT significantly inhibit DNA synthesis in otherwise unstimulated Jurkat (E 6.1) cells. Inhibition is generally most prominent in cells from mid log phase growth. In complete medium the bone healing EMF inhibits [3H] thymidine uptake of the latter cells by almost 50% vs. 20-25% inhibition by 60 Hz fields. Cells in conditioned medium are even more sensitive to EMFs with inhibition up to ca. 60%. The effects of the 0.1 and 0.4 mT power frequency EMFs were very similar suggesting saturation at 0.1 mT or lower. |
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Indiana University School of Medicine at Indiana State University, Terre Haute Center for Medical Education, 47809, USA |
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0014-5793 |
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PMID:9323024 |
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Call Number |
IT'IS @ evaj @ |
Serial |
362 |
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Author |
Gabriel, C. |
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Title |
Comments on 'dielectric properties of the skin' |
Type |
Journal Article |
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Year |
1997 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys Med Biol |
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Volume |
42 |
Issue |
8 |
Pages |
1671-1673 |
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Keywords |
Electric Conductivity; Electrodes; Electrophysiology/methods; Foot; Forearm; Hand; Humans; *Skin Physiological Phenomena |
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0031-9155 |
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WP2 Exposure measurements |
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PMID:9279914 |
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CNR-ISIB @ paolo.ravazzani @ |
Serial |
217 |
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Author |
Hisamitsu, T.; Narita, K.; Kasahara, T.; Seto, A.; Yu, Y.; Asano, K. |
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Title |
Induction of apoptosis in human leukemic cells by magnetic fields |
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Journal Article |
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Year |
1997 |
Publication |
The Japanese Journal of Physiology |
Abbreviated Journal |
Jpn J Physiol |
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Volume |
47 |
Issue |
3 |
Pages |
307-310 |
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Keywords |
*Apoptosis; Blood Cells/physiology; DNA Fragmentation; DNA, Neoplasm/genetics; *Electromagnetic Fields; Electrophoresis, Agar Gel; HL-60 Cells; Humans; Leukemia, Myeloid/genetics/*pathology; Leukocytes/physiology; Neutrophils/physiology; Tumor Cells, Cultured |
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Abstract |
When human myelogenous leukemic cell lines, HL-60 and ML-1, were exposed to 50 Hz electromagnetic fields (EMFs), nucleosome-sized DNA fragmentation (a biochemical marker of apoptosis) was induced as assessed by agarose gel electrophoresis. However, EMFs could not induce detectable DNA fragmentation in either human peripheral blood leukocytes or polymorphonuclear cells. The minimum exposure period required for the onset of DNA fragmentation in leukemic cells was 1.0 h. Although adverse effects of EMFs on human health have been reported, the apoptosis-inducing action of EMFs on leukemic cells may suggest a possible medical application. |
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Department of Physiology, School of Medicine, Showa University, Tokyo, Japan. tadashi@med.showa-u.ac.jp |
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0021-521X |
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PMID:9271162 |
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Call Number |
IT'IS @ evaj @ |
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317 |
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Author |
Feychting, M.; Forssen, U.; Floderus, B. |
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Title |
Occupational and residential magnetic field exposure and leukemia and central nervous system tumors |
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Journal Article |
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Year |
1997 |
Publication |
Epidemiology (Cambridge, Mass.) |
Abbreviated Journal |
Epidemiology |
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Volume |
8 |
Issue |
4 |
Pages |
384-389 |
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Keywords |
Astrocytoma/epidemiology/etiology; Case-Control Studies; Central Nervous System Neoplasms/*epidemiology/etiology; Confidence Intervals; Electromagnetic Fields/*adverse effects; Environmental Exposure/*adverse effects/analysis; Female; *Housing; Humans; Leukemia/*epidemiology/etiology; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology/etiology; Leukemia, Myeloid/epidemiology/etiology; Logistic Models; Male; Occupational Exposure/adverse effects/analysis; Risk; Sweden/epidemiology |
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Abstract |
Studies of magnetic field exposure and cancer have focused on either residential or occupational exposure. We conducted a case-control study taking into account both exposure sources. We identified leukemia and central nervous system tumor cases and controls from a population living within 300 m of transmission lines in Sweden. We have previously reported results considering residential exposure alone. Here, we evaluate the effect of occupational exposure and of the combined exposures. We estimated residential exposure through calculations of the magnetic fields generated by power lines. We obtained information about occupation from censuses and linked the occupations to a job-exposure matrix based on magnetic field measurements. For occupational exposure of > or = 0.2 microT, we estimated the relative risk for leukemia to be 1.7 [95% confidence interval (CI) = 1.1-2.7]. The increased risk was confined to acute myeloid and chronic lymphocytic leukemia. For residential exposure of > or = 0.2 microT, the relative risk for leukemia was estimated at 1.3 (95% CI = 0.8-2.2), with higher risk estimates for acute and chronic myeloid leukemia. We estimated the relative risk for leukemia among subjects highly exposed both at home and at work to be 3.7 (95% CI = 1.5-9.4). These results provide support for an association between magnetic field exposure and leukemia. Relative risks for nervous system tumors were close to unity. |
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Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden |
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English |
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ISSN |
1044-3983 |
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Notes |
PMID:9209851 |
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no |
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Call Number |
ITIS @ murbach @ |
Serial |
157 |
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Author |
Dhabhar, F.S.; McEwen, B.S.; Spencer, R.L. |
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Title |
Adaptation to prolonged or repeated stress--comparison between rat strains showing intrinsic differences in reactivity to acute stress |
Type |
Journal Article |
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Year |
1997 |
Publication |
Neuroendocrinology |
Abbreviated Journal |
Neuroendocrinology |
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Volume |
65 |
Issue |
5 |
Pages |
360-368 |
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Keywords |
*Adaptation, Physiological; Adrenal Glands/physiopathology; Adrenocorticotropic Hormone/blood; Animals; Corticosterone/blood; Hypothalamus/physiopathology; Kinetics; Pituitary Gland/physiopathology; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Restraint, Physical; Species Specificity; Stress, Physiological/etiology/*physiopathology |
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Abstract |
Sprague-Dawley (SD), Fischer 344 (F344) and Lewis (LEW) rats are used in a wide variety of laboratory studies. Compared to SD and LEW rats, F344 rats show significantly greater activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to acute stress, or to immunologic challenge. These differences in HPA axis responsivity have been the basis for numerous studies investigating strain differences in immunological and behavioral parameters. However, strain differences in the adaptation of the HPA axis response to prolonged stress, or to repeated stress, have not been investigated. This series of studies demonstrates that F344 rats maintain significantly higher ACTH and corticosterone levels than SD and LEW rats during a single prolonged stress session. Furthermore, F344 rats show virtually no habituation or adaptation of the corticosterone stress response during a single prolonged (4 h) stress session, or during stress sessions repeated over a period of 10 days. In contrast, SD and LEW rats show habituation both within and across stress sessions. Strain differences in HPA axis responsivity are also reflected in the significant adrenal hypertrophy observed in F344 rats (but not in SD or LEW rats) following repeated stress. These results show that strain differences in HPA axis responsivity, which are observed under conditions of acute stress, are further amplified during prolonged or repeated stress. These differences under prolonged or repeated stress conditions may consequently magnify the behavioral and immunological differences observed between strains under basal as well as challenged conditions. |
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Laboratory of Neuroendocrinology, The Rockefeller University, New York, N.Y. 10021, USA. dhabhar@rockvax.rockefeller.edu |
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ISSN |
0028-3835 |
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Area |
WP6 In vivo |
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Notes |
PMID:9158068 |
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Call Number |
TIHO @ Maren.Fedrowitz @ |
Serial |
117 |
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