| |
Records |
Warning: mysql_fetch_field() expects parameter 2 to be long, string given in /home/arimmora/public_html/refbase/includes/include.inc.php on line 309
Links  |
|
Author |
Kaune, W.T. |
|
| |
Title |
Comment on “designing EMF experiments: what is required to characterize 'exposure'?” |
Type |
Journal Article |
| |
Year |
1995 |
Publication |
Bioelectromagnetics |
Abbreviated Journal |
Bioelectromagnetics |
|
| |
Volume |
16 |
Issue |
6 |
Pages |
402-404 |
|
| |
Keywords |
Animals; Biophysical Phenomena; Biophysics; Electromagnetic Fields/*adverse effects; Epidemiologic Methods; Humans; Research Design |
|
| |
Abstract |
Dr. Peter Valberg has written an excellent and clear paper describing our current understanding of the many facets of characterizing exposure to extremely-low-frequency (ELF) electric and magnetic fields. Dr. Valberg has directed his paper to the characterization of exposures used in laboratory experimentation. In this context, it seems to me that Valberg's program of exposure characterization can be accomplished with currently available instrumentation and with relatively modest effort. Thus, I have no fundamental problems with his recommendations and, really, have only a few minor comments to make. However, if one argues that Valberg's recommendations should be extended to the characterization of exposure in epidemiological research, I have serious reservations, which I will mention briefly at the end of this commentary. |
|
| |
Address |
EM Factors, Richland, Washington, USA |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0197-8462 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:8789072 |
Approved |
no |
|
| |
Call Number |
CBM.UAM @ ccobaleda @ |
Serial |
497 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Fam, W.Z.; Mikhail, E.L. |
|
| |
Title |
Lymphoma induced in mice chronically exposed to very strong low-frequency electromagnetic field |
Type |
Journal Article |
| |
Year |
1996 |
Publication |
Cancer Letters |
Abbreviated Journal |
Cancer Lett |
|
| |
Volume |
105 |
Issue |
2 |
Pages |
257-269 |
|
| |
Keywords |
Animals; Atrophy; Chi-Square Distribution; Cohort Effect; Electromagnetic Fields/*adverse effects; Female; Hyperplasia; Lymph Nodes/pathology; Lymphatic System/pathology/*radiation effects; Lymphoma/*etiology/pathology; Male; Mice; Mice, Inbred Strains; Peyer's Patches/pathology; Precancerous Conditions/*etiology; Pregnancy; Prenatal Exposure Delayed Effects; Thymus Gland/pathology |
|
| |
Abstract |
Three successive generations of CFW mice were exposed to a 25-mT (250,000 mG), 60-Hz electromagnetic field for prolonged periods. At the end of the exposure period, animals from both the exposed and control groups were sacrificed for tests. A complete autopsy was performed and tissue sections were taken from the main organs for histopathological examination. The results from the pathological findings in the various animals were classified under the following categories: (1) normal; (2) lymphoid hyperplasia; (3) premalignant changes; (4) early lymphoma; (5) advanced lymphoma. The three first-generation animals developed generalized lymphoid hyperplasia. In the second-generation animals, 5% developed premalignant changes, and 15.8% had lymphoid hyperplasia. In addition, 4 female mice left in the field for 418 days developed malignant lymphoma. In the third-generation animals, 58% developed premalignant changes or malignant lymphoma. An additional 30% had lymphoid hyperplasia. Statistical analysis of the data using the Mantel-Haenszel test for the difference in the prevalence of lymphoma between the exposed and control groups shows a very significant difference for the male groups (P < 0.001), the female groups (P < 0.001), and all animals combined (P < 0.001). The results suggest a cause-effect relationship between chronic exposure to very strong 60-Hz magnetic field for prolonged period and the development of malignant lymphoma in CFW mice. |
|
| |
Address |
Department of Electrical Engineering, Technical University of Nova Scotia, Halifax, Canada |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0304-3835 |
ISBN |
|
Medium |
|
|
| |
Area |
WP6 In vivo |
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:8697452 |
Approved |
no |
|
| |
Call Number |
ITEM @ geertje.lewin @ |
Serial |
138 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Mevissen, M.; Lerchl, A.; Szamel, M.; Loscher, W. |
|
| |
Title |
Exposure of DMBA-treated female rats in a 50-Hz, 50 microTesla magnetic field: effects on mammary tumor growth, melatonin levels, and T lymphocyte activation |
Type |
Journal Article |
| |
Year |
1996 |
Publication |
Carcinogenesis |
Abbreviated Journal |
Carcinogenesis |
|
| |
Volume |
17 |
Issue |
5 |
Pages |
903-910 |
|
| |
Keywords |
9,10-Dimethyl-1,2-benzanthracene; Animals; Female; *Lymphocyte Activation; Magnetics/*adverse effects; Mammary Neoplasms, Experimental/blood/*etiology/immunology; Melatonin/*blood; Rats; Rats, Sprague-Dawley; T-Lymphocytes/*immunology |
|
| |
Abstract |
There is growing public concern about the possible health risks, particularly increased cancer risks of exposure to magnetic fields (MF) associated with power distribution systems. Recently, we have started a series of animal studies to investigate this issue, using the DMBA (7,12-dimethylbenz[a]anthracene) model of breast cancer in female rats. In the present study, female rats were chronically exposed to a 50-Hz, 50 microTesla (microT) MF with or without DMBA treatment. Because alterations in circulating levels of the pineal hormone melatonin and impaired immune system functions have been involved in breast cancer growth, and both melatonin and immune system are thought to be targets for MF-effects, serum melatonin and the proliferative capacity of splenic lymphocytes were determined in MF-exposed and sham-exposed rats. For this purpose, 216 female Sprague-Dawley rats were divided into four groups. Two of the groups (with 99 animals each) received oral applications of DMBA and were either sham-exposed or exposed in a 50-Hz, 50 microT MF for 24 h/day 7 days/week for a period of 91 days. The other two groups (9 animals each) were either sham-exposed or MF-exposed without DMBA treatment. The exposure chambers and all other environmental factors were identical for MF-exposed and sham-exposed animals. The DMBA-treated animals were palpated once weekly to assess the development of mammary tumors. At the end of the three-month period of MF exposure, the number and size of mammary tumors was determined by autopsy. In controls, DMBA induced tumors in approximately 55% of the animals within the 3 month period of sham-exposure. Already 8 weeks after DMBA application, the MF-exposed group exhibited significantly more tumors than sham-exposed animals. At time of autopsy, significantly more MF-exposed DMBA-treated rats exhibited macroscopically visible mammary tumors than DMBA-treated controls, thus indicating that MF exposure enhances the development and growth of cancers in this model. Comparison of the data from 50 microT with recent data from other flux densities indicated that long-term MF exposure of DMBA-treated rats increases the incidence of palpable and/or macroscopically visible mammary tumors in a highly dose-related fashion. Determination of nocturnal serum melatonin after 9 and 12 weeks of exposure at 50 microT did not yield significant differences between MF-exposed rats and sham-exposed controls, whereas a marked suppression of T cell proliferative capacity was seen in MF exposed rats. The data add further evidence to the hypothesis that hormone-dependent tissues such as breast might be particularly sensitive to MF-effects and indicate that immune system depression is involved in the increased breast cancer growth observed in MF exposed rats. |
|
| |
Address |
Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0143-3334 |
ISBN |
|
Medium |
|
|
| |
Area |
WP6 In vivo |
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:8640936 |
Approved |
no |
|
| |
Call Number |
ITEM @ geertje.lewin @ |
Serial |
131 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Liburdy, R.P.; Sloma, T.R.; Sokolic, R.; Yaswen, P. |
|
| |
Title |
ELF magnetic fields, breast cancer, and melatonin: 60 Hz fields block melatonin's oncostatic action on ER+ breast cancer cell proliferation |
Type |
Journal Article |
| |
Year |
1993 |
Publication |
Journal of Pineal Research |
Abbreviated Journal |
J Pineal Res |
|
| |
Volume |
14 |
Issue |
2 |
Pages |
89-97 |
|
| |
Keywords |
Adenocarcinoma/drug therapy/metabolism/*pathology; Breast Neoplasms/drug therapy/metabolism/*pathology; Cell Division/radiation effects; *Electromagnetic Fields; Humans; Melatonin/*antagonists & inhibitors/pharmacology; Radiation; Receptors, Estrogen/*metabolism; Tumor Cells, Cultured |
|
| |
Abstract |
In this study we investigated whether a 60 Hz magnetic field can act at the cellular level to influence the growth of human estrogen-dependent breast cancer cells. Our experimental design assessed cell proliferation of a human breast cancer cell line, MCF-7, in the absence or the presence of melatonin which inhibits growth at a physiological concentration of 10(-9) M. In three experiments, continuous exposure to average sinusoidal 60 Hz magnetic fields of 1.90 +/- 0.01, 2.40 +/- 0.70, and 2.53 +/- 0.50 mG, or simultaneous exposure in matched incubators to average 60 Hz magnetic fields of 10.4 +/- 2.12, 11.95 +/- 2.73, and 11.95 +/- 3.28 mG, respectively, had no effect on cell proliferation in the absence of melatonin. When MCF-7 cells were cultured in the presence of 10(-9) M melatonin, an 18% inhibition of growth was observed for cells in a 2.40 +/- 0.70 mG field. This effect was blocked by a 60 Hz magnetic field of 11.95 +/- 2.75 mG. In a second experiment, a 27% inhibition of MCF-7 cell growth was observed for cells in a 2.53 +/- 0.50 mG magnetic field, and this was blocked by a 60 Hz magnetic field of 11.95 +/- 3.28 mG. These results provide the first evidence that ELF frequency magnetic fields can act at the cellular levels to enhance breast cancer cell proliferation by blocking melatonin's natural oncostatic action. In addition, there appears to be a dose threshold between 2 and 12 mG. The mechanism(s) of action is unknown and may involve modulation of signal transduction events associated with melatonin's regulation of cell growth. |
|
| |
Address |
Department of Cell and Molecular Biology, Life Sciences Division, Lawrence Berkeley Laboratory, UC Berkeley, CA 94720 |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0742-3098 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:8320637 |
Approved |
no |
|
| |
Call Number |
IT'IS @ evaj @ |
Serial |
343 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Lin, H.; Goodman, R.; Shirley-Henderson, A. |
|
| |
Title |
Specific region of the c-myc promoter is responsive to electric and magnetic fields |
Type |
Journal Article |
| |
Year |
1994 |
Publication |
Journal of Cellular Biochemistry |
Abbreviated Journal |
J Cell Biochem |
|
| |
Volume |
54 |
Issue |
3 |
Pages |
281-288 |
|
| |
Keywords |
Animals; *Electromagnetic Fields; Gene Expression Regulation/*radiation effects; Genes, myc/*radiation effects; HeLa Cells; Humans; *Magnetics; Mice; Multiple Myeloma; Promoter Regions, Genetic/*radiation effects; Proto-Oncogene Proteins c-myc/biosynthesis; Recombinant Fusion Proteins/biosynthesis; Transfection; Tumor Cells, Cultured |
|
| |
Abstract |
The level of c-myc transcripts is increased in cells exposed to extremely low frequency (elf) electromagnetic (EM) fields at 60 Hz. The aim of the present experiments was to determine if regulatory regions upstream of the c-myc gene modulate the response to EM fields. DNA upstream of P1 of both mouse and human c-myc genes was transfected into cells as CAT constructs. The presence of DNA 5' to the human or mouse myc genes results in increased expression of CAT following 20 min exposures of cells to 60 Hz elf EM fields. Specific portions of the human upstream DNA were deleted and introduced into cells. The region responsive to EM fields is located between -353 and -1,257 relative to the P1 promoter. |
|
| |
Address |
Department of Pathology, Columbia University Health Sciences, New York, New York 10032 |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0730-2312 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:8200908 |
Approved |
no |
|
| |
Call Number |
IT'IS @ evaj @ |
Serial |
344 |
|
| Permanent link to this record |
