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Author (up) Barteri, M.; De Carolis, R.; Marinelli, F.; Tomassetti, G.; Montemiglio, L.C. url  doi
openurl 
  Title Effects of microwaves (900 MHz) on peroxidase systems: a comparison between lactoperoxidase and horseradish peroxidase Type Journal Article
  Year 2015 Publication Electromagnetic Biology and Medicine Abbreviated Journal  
  Volume 00 Issue 00 Pages 1-7  
  Keywords 900 mhz; 900 MHz; electromagneti fields; enzyme kinetics; horseradish peroxidase; lactoperoxidase; microwaves; radiofrequency; peroxidase; enzyme; kinetics  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Informa Healthcare USA, Inc Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area WP5 In vitro Expedition Conference  
  Notes Approved no  
  Call Number UNIBAS @ david.schuermann @ Serial 630  
Permanent link to this record
 

 
Author (up) Bateman, C.M.; Alpar, D.; Ford, A.M.; Colman, S.M.; Wren, D.; Morgan, M.; Kearney, L.; Greaves, M. url  doi
openurl 
  Title Evolutionary trajectories of hyperdiploid ALL in monozygotic twins Type Journal Article
  Year 2015 Publication Leukemia Abbreviated Journal Leukemia  
  Volume 29 Issue 1 Pages 58-65  
  Keywords  
  Abstract Identical twins have provided unique insights on timing or sequence of genetic events in acute lymphoblastic leukaemia (ALL). To date, this has mainly focused on ALL with MLL or ETV6-RUNX1 fusions, with hyperdiploid ALL remaining less well characterised. We examined three pairs of monozygotic twins, two concordant and one discordant for hyperdiploid ALL, for single-nucleotide polymorphism (SNP)-defined copy number alterations (CNAs), IGH/L plus TCR gene rearrangements and mutations in NRAS, KRAS, FLT3 and PTPN11 genes. We performed whole exome sequencing in one concordant twin pair. Potential 'driver' CNAs were low, 0-3 per case, and all were different within a pair. One patient had an NRAS mutation that was lacking from leukaemic cells of the twin sibling. By exome sequencing, there were 12 nonsynonymous mutations found in one twin and 5 in the other, one of which in SCL44A2 was shared or identical. Concordant pairs had some identical IGH/L and TCR rearrangements. In the twin pair with discordant hyperdiploid ALL, the healthy co-twin had persistent low level hyperdiploid CD19+ cells that lacked a CNA present in the ALL cells of her sibling. From these data, we propose that hyperdiploid ALL arises in a pre-B cell in utero and mutational changes necessary for clinical ALL accumulate subclonally and postnatally.  
  Address Centre for Evolution and Cancer, The Institute of Cancer Research, Sutton, UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0887-6924 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24897505 Approved no  
  Call Number CBM.UAM @ ccobaleda @ Serial 544  
Permanent link to this record
 

 
Author (up) Boga, A.; Emre, M.; Sertdemir, Y.; Akillioglu, K.; Binokay, S.; Demirhan, O. url  doi
openurl 
  Title The effect of 900 and 1800MHz GSM-like radiofrequency irradiation and nicotine sulfate administration on the embryonic development of Xenopus laevis Type Journal Article
  Year 2015 Publication Ecotoxicology and Environmental Safety Abbreviated Journal  
  Volume 113 Issue May 2010 Pages 378-390  
  Keywords GSM-like radiofrequency radiation; Nicotine sulfate; Teratogenicity; Xenopus laevis; gsm-like radiofrequency radiation  
  Abstract The aim of this study was to investigate the effects of GSM-like radiofrequency electromagnetic radiation (RF EMR) and nicotine sulfate (NS) exposure on Xenopus embryonic development.The developmental effects of GSM-like RF-EMR (900–1800 MHz, at a SAR value of 1 W/kg and NS on Xenopus laevis embryos were investigated). Following the application of radiofrequency radiation and/or NS administration, the embryos were closely examined in order to determine their possible teratogenic effects. Xenopus frogs obtained from the Department of Physiology of the Cukurova University, in accordance described by the Standard Guide of the American Society for Testing and Materials (ASTM). Following the exposure of Xenopus embryos to RF-EMR at 900 and 1800 MHz (1.0 W/kg) for 4, 6 and 8 h; the whole body specific energy absorption rate (SAR) of the embryos was calculated. With the exception of irradiation at 1800 MHz no dramatic developmental anomalies were observed in the Xenopus embryos in association with RF-EMR applications. Combined RF-EMR and NS applications resulted in dramatic abnormalities and death among the Xenopus embryos. The study results indicated that GSM-like RF-EMR (e.g. radiation from cell phones) was not as harmful to Xenopus embryos as might have been expected. However, the combined effects of GSM-like RF-EMR and NS on Xenopus embryos were more severe than the effect of RF-EMR or NS alone. In conclusion, the study results appear to suggest that the combined use of nicotine and cell phones might result in more pronounced detrimental effects on the health of smokers.  
  Address  
  Corporate Author Thesis  
  Publisher Elsevier Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area WP5 In vitro; WP6 In vivo Expedition Conference  
  Notes Approved no  
  Call Number UNIBAS @ david.schuermann @ Serial 609  
Permanent link to this record
 

 
Author (up) Edelman, N.B.; Fritz, T.; Nimpf, S.; Pichler, P.; Lauwers, M.; Hickman, R.W.; Papadaki-Anastasopoulou, A.; Ushakova, L.; Heuser, T.; Resch, G.P.; Saunders, M.; Shaw, J.A.; Keays, D.A. url  doi
openurl 
  Title No evidence for intracellular magnetite in putative vertebrate magnetoreceptors identified by magnetic screening Type Journal Article
  Year 2015 Publication Proceedings of the National Academy of Sciences of the United States of America Abbreviated Journal Proc Natl Acad Sci U S A  
  Volume 112 Issue 1 Pages 262-267  
  Keywords magnetite; magnetoreception; pigeons  
  Abstract The cellular basis of the magnetic sense remains an unsolved scientific mystery. One theory that aims to explain how animals detect the magnetic field is the magnetite hypothesis. It argues that intracellular crystals of the iron oxide magnetite (Fe3O4) are coupled to mechanosensitive channels that elicit neuronal activity in specialized sensory cells. Attempts to find these primary sensors have largely relied on the Prussian Blue stain that labels cells rich in ferric iron. This method has proved problematic as it has led investigators to conflate iron-rich macrophages with magnetoreceptors. An alternative approach developed by Eder et al. [Eder SH, et al. (2012) Proc Natl Acad Sci USA 109(30):12022-12027] is to identify candidate magnetoreceptive cells based on their magnetic moment. Here, we explore the utility of this method by undertaking a screen for magnetic cells in the pigeon. We report the identification of a small number of cells (1 in 476,000) with large magnetic moments (8-106 fAm(2)) from various tissues. The development of single-cell correlative light and electron microscopy (CLEM) coupled with electron energy loss spectroscopy (EELS) and energy-filtered transmission electron microscopy (EFTEM) permitted subcellular analysis of magnetic cells. This revealed the presence of extracellular structures composed of iron, titanium, and chromium accounting for the magnetic properties of these cells. Application of single-cell CLEM to magnetic cells from the trout failed to identify any intracellular structures consistent with biogenically derived magnetite. Our work illustrates the need for new methods to test the magnetite hypothesis of magnetosensation.  
  Address Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), 1030 Vienna, Austria; keays@imp.ac.at  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0027-8424 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25535350 Approved no  
  Call Number CBM.UAM @ ccobaleda @ Serial 588  
Permanent link to this record
 

 
Author (up) Glushkova, O.V.; Khrenov, M.O.; Novoselova, T.V.; Lunin, S.M.; Parfenyuk, S.B.; Alekseev, S.I.; Fesenko, E.E.; Novoselova, E.G. url  doi
openurl 
  Title The role of the NF-κB, SAPK/JNK, and TLR4 signalling pathways in the responses of RAW 264.7 cells to extremely low-intensity microwaves Type Journal Article
  Year 2015 Publication International Journal of Radiation Biology Abbreviated Journal  
  Volume Issue Pages 1-8  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area WP5 In vitro Expedition Conference  
  Notes Approved no  
  Call Number UNIBAS @ david.schuermann @ Serial 615  
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