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Pui, C. - H., Relling, M. V., & Downing, J. R. (2004). Acute lymphoblastic leukemia. N Engl J Med, 350(15), 1535–1548.
Keywords: Age Factors; Genotype; Humans; Molecular Biology; Mutation; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/*genetics; Prognosis; Translocation, Genetic
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Tomasetti, C., & Vogelstein, B. (2015). Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science, 347(6217), 78–81.
Abstract: Some tissue types give rise to human cancers millions of times more often than other tissue types. Although this has been recognized for more than a century, it has never been explained. Here, we show that the lifetime risk of cancers of many different types is strongly correlated (0.81) with the total number of divisions of the normal self-renewing cells maintaining that tissue's homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to “bad luck,” that is, random mutations arising during DNA replication in normal, noncancerous stem cells. This is important not only for understanding the disease but also for designing strategies to limit the mortality it causes.
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Nuccitelli, R., Pliquett, U., Chen, X., Ford, W., James Swanson, R., Beebe, S. J., et al. (2006). Nanosecond pulsed electric fields cause melanomas to self-destruct. Biochemical and Biophysical Research Communications, 343(2), 351–360.
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Hirota, T., Lee, J. W., St. John, P. C., Sawa, M., Iwaisako, K., Noguchi, T., et al. (2012). Identification of Small Molecule Activators of Cryptochrome. Science, 337(6098), 1094–1097.
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Winklhofer, M. (2012). An Avian Magnetometer. Science, 336(6084), 991–992.
Abstract: Homing pigeons have remarkable navigational
skills that allow them to
fi nd their way back to the loft when
released from an unfamiliar location hundreds
of miles away. To perform such a feat,
they rely on various cues, such as odors and
Earth’s magnetic fi eld ( 1, 2). Yet, how birds
and other animals obtain magnetic-fi eld information
has been a mystery. On page 1054 of
this issue, Wu and Dickman ( 3) report how
this information is neurally encoded and suggest
a candidate magnetic sensory organ in
the inner ear of the pigeon ( 4).
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