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Author (up) Antonini, R.A.; Benfante, R.; Gotti, C.; Moretti, M.; Kuster, N.; Schuderer, J.; Clementi, F.; Fornasari, D. url  doi
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  Title Extremely low-frequency electromagnetic field (ELF-EMF) does not affect the expression of alpha3, alpha5 and alpha7 nicotinic receptor subunit genes in SH-SY5Y neuroblastoma cell line Type Journal Article
  Year 2006 Publication Toxicology Letters Abbreviated Journal Toxicol Lett  
  Volume 164 Issue 3 Pages 268-277  
  Keywords Bicyclo Compounds, Heterocyclic/pharmacology; Blotting, Northern; Bungarotoxins/pharmacology; Cell Line, Tumor; Electromagnetic Fields/*adverse effects; Gene Expression/*radiation effects; Humans; Nerve Tissue Proteins/*genetics/metabolism; Neuroblastoma/pathology; Pyridines/pharmacology; RNA, Messenger/genetics; Radioligand Assay; Receptors, Nicotinic/*genetics/metabolism  
  Abstract Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a number of functional processes, including cognition, learning and memory, and alterations in their expression and/or activity have been implicated in various neurological disorders such as Alzheimer's disease (AD), Parkinson's disease and schizophrenia. Epidemiological studies have shown that exposure to electromagnetic fields (EMF) may contribute to the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. Given the role of nAChRs in physiological and pathological conditions, we wondered whether an extremely low-frequency electromagnetic field (ELF-EMF) may affect the expression of the molecules involved in neurodegenerative processes. In order to investigate this possibility, we studied the expression of alpha3, alpha5 and alpha7 nicotinic subunits upon exposure of the SH-SY5Y human neuroblastoma cell line to a 50 Hz power-line magnetic field in a “blind trial” system; various magnetic flux densities and exposure times were applied. Our studies show that the expression of some relevant components of the cholinergic nicotinic system, which is one of the most affected neurotransmission systems in AD, did not undergo any change at molecular level by environmental exposure to ELF-EMF.  
  Address Department of Pharmacology, School of Medicine, University of Milan, via Vanvitelli 32, 20129 Milan, Italy  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0378-4274 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16513298 Approved no  
  Call Number ITIS @ murbach @ Serial 163  
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