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Author (up) Rehe, K.; Wilson, K.; Bomken, S.; Williamson, D.; Irving, J.; den Boer, M.L.; Stanulla, M.; Schrappe, M.; Hall, A.G.; Heidenreich, O.; Vormoor, J. url  doi
openurl 
  Title Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations Type Journal Article
  Year 2012 Publication EMBO Molecular Medicine Abbreviated Journal EMBO Mol Med  
  Volume Issue Pages n/a-n/a  
  Keywords  
  Abstract Leukaemia-propagating cells are more frequent in high-risk acute B lymphoblastic
leukaemia than in many malignancies that follow a hierarchical cancer
stem cell model. It is unclear whether this characteristic can be more universally
applied to patients from non-‘high-risk’ sub-groups and across a broad range of
cellular immunophenotypes. Here, we demonstrate in a wide range of primary
patient samples and patient samples previously passaged through mice that
leukaemia-propagating cells are found in all populations defined by high or low
expression of the lymphoid differentiation markers CD10, CD20 or CD34. The
frequency of leukaemia-propagating cells and their engraftment kinetics do
not differ between these populations. Transcriptomic analysis of CD34high and
CD34low blasts establishes their difference and their similarity to comparable
normal progenitors at different stages of B-cell development. However, consistent
with the functional similarity of these populations, expression signatures
characteristic of leukaemia propagating cells in acute myeloid leukaemia fail to
distinguish between the different populations. Together, these findings suggest
that there is no stem cell hierarchy in acute B lymphoblastic leukaemia.		  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1757-4676 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number CBM.UAM @ ccobaleda @ Serial 233  
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