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Author  |
Beneduci, A.; Chidichimo, G.; Tripepi, S.; Perrotta, E.; Cufone, F. |
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Title |
Antiproliferative effect of millimeter radiation on human erythromyeloid leukemia cell line K562 in culture: ultrastructural- and metabolic-induced changes |
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Journal Article |
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Year |
2007 |
Publication |
Bioelectrochemistry (Amsterdam, Netherlands) |
Abbreviated Journal |
Bioelectrochemistry |
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Volume |
70 |
Issue |
2 |
Pages |
214-220 |
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Keywords |
Cell Proliferation/*drug effects; Cell Survival/*radiation effects; Dose-Response Relationship, Radiation; Glucose/*metabolism; Glycolysis/*radiation effects; Humans; K562 Cells; Metabolic Clearance Rate/radiation effects; *Microwaves; Radiation Dosage |
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Abstract |
In the present study we compared the proliferation behavior, the ultrastructural morphology and the glycolitic metabolism of K562 cells irradiated by low-power wide-band millimeter waves, with those of sham-exposed K562 cells (control), maintained in the same culture conditions. The gigaHertz radiation treatments, performed between 53-78 10(9) Hz, induced a noticeable inhibition of the cell proliferation that could be related to relevant ultrastructural changes. Such effects brought the irradiated cell system to lose the homeostasis and to trigger defense/reparatory mechanisms in order to reestablish a new steady state. (13)C-Nuclear magnetic resonance data on the kinetic of glucose metabolism demonstrated that the irradiated cells enhanced the glycolitic aerobic pathway, indicating that such system need to produce an extra-bioenergy. Most of the ATP synthesized served probably to perform the above processes resulting in a significant decrease of the proliferation rate without significant cell death increment. |
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Address |
Department of Chemistry, University of Calabria, Via P. Bucci Cubo 17/D 87036 Arcavacata di Rende (CS), Italy. beneduci@unical.it <beneduci@unical.it> |
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Language |
English |
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ISSN |
1567-5394 |
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Notes |
PMID:16959547 |
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no |
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Call Number |
IT'IS @ evaj @ |
Serial |
283 |
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