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Author  |
Hisamitsu, T.; Narita, K.; Kasahara, T.; Seto, A.; Yu, Y.; Asano, K. |
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Title |
Induction of apoptosis in human leukemic cells by magnetic fields |
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Journal Article |
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Year |
1997 |
Publication |
The Japanese Journal of Physiology |
Abbreviated Journal |
Jpn J Physiol |
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Volume |
47 |
Issue |
3 |
Pages |
307-310 |
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Keywords |
*Apoptosis; Blood Cells/physiology; DNA Fragmentation; DNA, Neoplasm/genetics; *Electromagnetic Fields; Electrophoresis, Agar Gel; HL-60 Cells; Humans; Leukemia, Myeloid/genetics/*pathology; Leukocytes/physiology; Neutrophils/physiology; Tumor Cells, Cultured |
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Abstract |
When human myelogenous leukemic cell lines, HL-60 and ML-1, were exposed to 50 Hz electromagnetic fields (EMFs), nucleosome-sized DNA fragmentation (a biochemical marker of apoptosis) was induced as assessed by agarose gel electrophoresis. However, EMFs could not induce detectable DNA fragmentation in either human peripheral blood leukocytes or polymorphonuclear cells. The minimum exposure period required for the onset of DNA fragmentation in leukemic cells was 1.0 h. Although adverse effects of EMFs on human health have been reported, the apoptosis-inducing action of EMFs on leukemic cells may suggest a possible medical application. |
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Address |
Department of Physiology, School of Medicine, Showa University, Tokyo, Japan. tadashi@med.showa-u.ac.jp |
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Language |
English |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0021-521X |
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Notes |
PMID:9271162 |
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no |
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Call Number |
IT'IS @ evaj @ |
Serial |
317 |
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