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Author (up) Walleczek, J.; Liburdy, R.P. url  openurl
  Title Nonthermal 60 Hz sinusoidal magnetic-field exposure enhances 45Ca2+ uptake in rat thymocytes: dependence on mitogen activation Type Journal Article
  Year 1990 Publication FEBS Letters Abbreviated Journal FEBS Lett  
  Volume 271 Issue 1-2 Pages 157-160  
  Keywords Animals; Calcium/*metabolism; Cell Membrane/metabolism; Concanavalin A/*pharmacology; *Electromagnetic Fields; Lymphocyte Activation/*drug effects; Male; Rats; Rats, Inbred Strains; T-Lymphocytes/*metabolism  
  Abstract The effect of a 60 Hz sinusoidal magnetic field of nonthermal intensity on Ca2+ metabolism in rat thymic lymphocytes (thymocytes) was assessed in resting cells and in cells activated with the mitogen Concanavalin A (Con A). A 60 min exposure at 37 degrees C to an induced electric field of 1.0 mV/cm produced an average 2.7-fold increase in Con A-dependent 45Ca2(+)-uptake compared to non-exposed, isothermal control cells. In contrast, 45Ca2+ uptake remained unaltered during exposure of resting thymocytes. It was also found that thymocytes with a diminished ability to mobilize Ca2+ in response to Con A were most sensitive to the 60 Hz magnetic field. Although the precise mechanism of field interaction is at present unknown, modulation of Ca2+ metabolism during cell activation may represent a common pathway for field coupling to cellular systems.  
  Address Research Medicine and Radiation Biophysics Division, Lawrence Berkeley Laboratory, University of California 94720  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0014-5793 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:2226799 Approved no  
  Call Number IT'IS @ evaj @ Serial 428  
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