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Author  |
Corces-Zimmerman, M.R.; Majeti, R. |
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Title |
Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis |
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Journal Article |
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Year |
2014 |
Publication |
Leukemia |
Abbreviated Journal |
Leukemia |
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Volume |
28 |
Issue |
12 |
Pages |
2276-2282 |
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Abstract |
Cancer has been shown to result from the sequential acquisition of genetic alterations in a single lineage of cells. In leukemia, increasing evidence has supported the idea that this accumulation of mutations occurs in self-renewing hematopoietic stem cells (HSCs). These HSCs containing some, but not all, leukemia-specific mutations have been termed as pre-leukemic. Multiple recent studies have sought to understand these pre-leukemic HSCs and determine to what extent they contribute to leukemogenesis. These studies have elucidated patterns in mutation acquisition in leukemia, demonstrated resistance of pre-leukemic cells to standard induction chemotherapy and identified these pre-leukemic cells as a putative reservoir for the generation of relapsed disease. When combined with decades of research on clonal evolution in leukemia, mouse models of leukemogenesis, and recent massively parallel sequencing-based studies of primary patient leukemia, studies of pre-leukemic HSCs begin to piece together the evolutionary puzzle of leukemogenesis. These results have broad implications for leukemia treatment, targeted therapies, minimal residual disease monitoring and early detection screening. |
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Address |
1] Program in Cancer Biology, Stanford Cancer Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Ludwig Center, Stanford, CA, USA [2] Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA |
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Language |
English |
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ISSN |
0887-6924 |
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Notes |
PMID:25005245 |
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no |
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Call Number |
CBM.UAM @ ccobaleda @ |
Serial |
539 |
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