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Author (up) Alpar, D.; Wren, D.; Ermini, L.; Mansur, M.B.; van Delft, F.W.; Bateman, C.M.; Titley, I.; Kearney, L.; Szczepanski, T.; de Castro, D.G.; Ford, A.M.; Potter, N.E.; Greaves, M. url  doi
openurl 
  Title Clonal origins of ETV6-RUNX1 acute lymphoblastic leukemia: studies in monozygotic twins Type Journal Article
  Year 2014 Publication Leukemia Abbreviated Journal Leukemia  
  Volume Issue Pages  
  Keywords  
  Abstract Studies on twins with concordant acute lymphoblastic leukemia (ALL) have revealed that ETV6-RUNX1 gene fusion is a common, pre-natal genetic event with other driver aberrations occurring subclonally and probably post-natally. The fetal cell type that is transformed by ETV6-RUNX1 is not identified by such studies or by the analysis of early B-cell lineage phenotype of derived progeny. Ongoing, clonal immunoglobulin (IG) and cross-lineage T-cell receptor (TCR) gene rearrangements are features of B-cell precursor leukemia and commence at the pro-B-cell stage of normal B-cell lineage development. We reasoned that shared clonal rearrangements of IG or TCR genes by concordant ALL in twins would be informative about the fetal cell type in which clonal advantage is elicited by ETV6-RUNX1. Five pairs of twins were analyzed for all varieties of IG and TCR gene rearrangements. All pairs showed identical incomplete or complete V(D)J junctions coupled with substantial, subclonal and divergent rearrangements. This pattern was endorsed by single cell genetic scrutiny in one twin pair. Our data suggest that the pre-leukemic initiating function of ETV6-RUNX1 fusion is associated with clonal expansion early in the fetal B-cell lineage.Leukemia accepted article preview online, 12 November 2014. doi:10.1038/leu.2014.322.  
  Address Centre for Evolution and Cancer, The Institute of Cancer Research – London, London, UK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0887-6924 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25388957 Approved no  
  Call Number CBM.UAM @ ccobaleda @ Serial 542  
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