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Author (up) Mo, W.-chuan; Zhang, Z.-jian; Liu, Y.; Bartlett, P.F.; He, R.-qiao url  openurl
  Title Magnetic shielding accelerates the proliferation of human neuroblastoma cell by promoting G1-phase progression Type Journal Article
  Year 2013 Publication PloS one Abbreviated Journal  
  Volume 8 Issue 1 Pages e54775-e54775  
  Keywords Cell Division; Cell Line, Tumor; G1 Phase; G2 Phase; Humans; Magnetic Fields; Neuroblastoma; Neuroblastoma: metabolism; Neuroblastoma: pathology  
  Abstract Organisms have been exposed to the geomagnetic field (GMF) throughout evolutionary history. Exposure to the hypomagnetic field (HMF) by deep magnetic shielding has recently been suggested to have a negative effect on the structure and function of the central nervous system, particularly during early development. Although changes in cell growth and differentiation have been observed in the HMF, the effects of the HMF on cell cycle progression still remain unclear. Here we show that continuous HMF exposure significantly increases the proliferation of human neuroblastoma (SH-SY5Y) cells. The acceleration of proliferation results from a forward shift of the cell cycle in G1-phase. The G2/M-phase progression is not affected in the HMF. Our data is the first to demonstrate that the HMF can stimulate the proliferation of SH-SY5Y cells by promoting cell cycle progression in the G1-phase. This provides a novel way to study the mechanism of cells in response to changes of environmental magnetic field including the GMF.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area WP5 In vitro Expedition Conference  
  Notes Approved no  
  Call Number UNIBAS @ david.schuermann @ Serial 565  
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