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Author (up) Michelle Rönnerblad, Robin Andersson, Tor Olofsson, Iyadh Douagi, Mohsen Karimi, Söen Lehmann, Ilka Hoof, Michiel de Hoon, Masayoshi Itoh, Sayaka Nagao-Sato, Hideya Kawaji, Timo Lassmann, Piero Carninci, Yoshihide Hayashizaki, Alistair R. R. Forrest, Albin Sandelin, Karl Ekwall, Erik Arner, and Andreas Lennartsson url  openurl
  Title Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation Type Journal Article
  Year 2014 Publication Blood Abbreviated Journal  
  Volume 123 Issue 17 Pages 79-89  
  Keywords  
  Abstract In development, epigenetic mechanisms such as DNA methylation have been suggested to provide a cellularmemoryto maintain multipotency but also stabilize cell fate decisions and direct lineage restriction. In this study, we set out to characterize changes in DNA methylation and gene expression during granulopoiesis using 4 distinct cell populations ranging from the oligopotent common myeloid progenitor stage to terminally differentiated neutrophils. We observed that differentially methylated sites (DMSs) generally show decreased methylation during granulopoiesis. Methylation appears to change at specific differentiation stages and overlap with changes in transcription and activity of key hematopoietic transcription factors. DMSs were preferentially located in areas distal to CpG islands and shores. Also, DMSs were overrepresented in enhancer elements and enriched in enhancers that become active during differentiation.Overall, this studydepicts in detail the epigenetic and transcriptional changes that occur during granulopoiesis and supports the role of DNA methylation as a regulatory mechanism in blood cell differentiation.  
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  Area WP5 In Vitro Expedition Conference  
  Notes Approved no  
  Call Number UNIBAS @ melissa.manser @ Serial 573  
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