|
Record |
Warning: mysql_fetch_field() expects parameter 2 to be long, string given in /home/arimmora/public_html/refbase/includes/include.inc.php on line 309
Links |
|
Author |
Manikonda, P.K.; Rajendra, P.; Devendranath, D.; Gunasekaran, B.; Channakeshava; Aradhya, S.R.S.; Sashidhar, R.B.; Subramanyam, C. |
|
|
Title |
Extremely low frequency magnetic fields induce oxidative stress in rat brain |
Type |
Journal Article |
|
Year |
2014 |
Publication |
General Physiology and Biophysics |
Abbreviated Journal |
Gen Physiol Biophys |
|
|
Volume |
33 |
Issue |
1 |
Pages |
81-90 |
|
|
Keywords |
Animals; Antioxidants/chemistry/metabolism; Brain/*pathology; Brain Mapping/methods; Cerebellum/metabolism; Cerebral Cortex/metabolism; Glutathione/chemistry/metabolism; Hippocampus/metabolism; *Lipid Peroxidation; *Magnetic Fields; Male; *Oxidative Stress; Rats; Rats, Wistar; *Reactive Oxygen Species; Superoxide Dismutase/metabolism |
|
|
Abstract |
The present investigation was conducted to understand the influence of long-term exposure of rats to extremely low frequency magnetic fields (ELF-MF), focusing on oxidative stress (OS) on different regions of rat's brain. Male Wistar rats (21-day-old) were exposed to ELF-MF (50 Hz; 50 and 100 microT) for 90 days continuously; hippocampal, cerebellar and cortical regions from rats were analyzed for (i) reactive oxygen species (ROS), (ii) metabolites indicative of OS and (iii) antioxidant enzymes. In comparison to control group rats, the rats that were continuously exposed to ELF-MF caused OS and altered glutathione (GSH/GSSG) levels in dose-dependent manner in all the regions of the brain. Accumulation of ROS, lipid peroxidation end products and activity of superoxide dismutase in different regions was in the descending order of cerebellum < hippocampus < cortex. Decrement in GSH/GSSG levels and increment in glutathione peroxidase activity were in the descending order of hippocampus < cerebellum < cortex. The continuous exposure to ELF-MF caused OS in all the examined regions of brain more significantly at 100 microT than at 50 microT. Varied influences observed in different regions of the brain, as documented in this study, may contribute to altered metabolic patterns in its related regions of the central nervous system, leading to aberrant neuronal functions. |
|
|
Address |
Department of Biochemistry, University College of Science, Osmania University, Hyderabad-500 007, AP, India. sashi_rao@yahoo.com |
|
|
Corporate Author |
|
Thesis |
|
|
|
Publisher |
|
Place of Publication |
|
Editor |
|
|
|
Language |
English |
Summary Language |
|
Original Title |
|
|
|
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
|
Series Volume |
|
Series Issue |
|
Edition |
|
|
|
ISSN |
0231-5882 |
ISBN |
|
Medium |
|
|
|
Area |
|
Expedition |
|
Conference |
|
|
|
Notes |
PMID:24334533 |
Approved |
no |
|
|
Call Number |
CBM.UAM @ ccobaleda @ |
Serial |
597 |
|
Permanent link to this record |