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Author  |
Nie, Y.; Chen, Y.; Mou, Y.; Weng, L.; Xu, Z.; Du, Y.; Wang, W.; Hou, Y.; Wang, T. |
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Title |
Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma |
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Journal Article |
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Year |
2013 |
Publication |
PloS one |
Abbreviated Journal |
PLoS One |
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Volume |
8 |
Issue |
11 |
Pages |
e72411 |
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Keywords |
Adaptive Immunity/physiology; Animals; Carcinoma, Hepatocellular/blood/*immunology/*therapy; Cell Line, Tumor; Cell Survival/physiology; Cytokines/blood; Female; Flow Cytometry; Immunity, Innate/physiology; Immunohistochemistry; Liver Neoplasms/blood/*immunology/*therapy; *Magnetic Fields; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; T-Lymphocytes/immunology |
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Abstract |
OBJECTIVE: Many studies have shown that magnetic fields (MF) inhibit tumor growth and influence the function of immune system. However, the effect of MF on mechanism of immunological function in tumor-bearing mice is still unclear. METHODS: In this study, tumor-bearing mice were prepared by subcutaneously inoculating Balb/c mice with hepatocarcinoma cell line H22. The mice were then exposed to a low frequency MF (0.4 T, 7.5 Hz) for 30 days. Survival rate, tumor growth and the innate and adaptive immune parameters were measured. RESULTS: MF treatment could prolong survival time (n = 28, p<0.05) and inhibit tumor growth (n = 9, p<0.01) in tumor-bearing mice. Moreover, this MF suppressed tumor-induced production of cytokines including interleukin-6 (IL-6), granulocyte colony- stimulating factor (G-CSF) and keratinocyte-derived chemokine (KC) (n = 9-10, p<0.05 or 0.01). Furthermore, MF exposure was associated with activation of macrophages and dendritic cells, enhanced profiles of CD4(+) T and CD8(+) T lymphocytes, the balance of Th17/Treg and reduced inhibitory function of Treg cells (n = 9-10, p<0.05 or 0.01) in the mice model. CONCLUSION: The inhibitory effect of MF on tumor growth was related to the improvement of immune function in the tumor-bearing mice. |
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Address |
State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, China |
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Language |
English |
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Original Title |
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Edition |
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ISSN |
1932-6203 |
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Notes |
PMID:24278103 |
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no |
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Call Number |
CBM.UAM @ ccobaleda @ |
Serial |
599 |
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