| |
Record |
Warning: mysql_fetch_field() expects parameter 2 to be long, string given in /home/arimmora/public_html/refbase/includes/include.inc.php on line 309
Links |
|
Author  |
Messiha, H.L.; Wongnate, T.; Chaiyen, P.; Jones, A.R.; Scrutton, N.S. |
|
| |
Title |
Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes |
Type |
Journal Article |
| |
Year |
2015 |
Publication |
Journal of the Royal Society, Interface / the Royal Society |
Abbreviated Journal |
|
|
| |
Volume |
12 |
Issue |
|
Pages |
20141155-20141155 |
|
| |
Keywords |
biochemistry; biophysics |
|
| |
Abstract |
Environmental exposure to electromagnetic fields is potentially carcinogenic. The radical pair mechanism is considered the most feasible mechanism of interaction between weak magnetic fields encountered in our environment and biochemical systems. Radicals are abundant in biology, both as free radicals and reaction intermediates in enzyme mechanisms. The catalytic cycles of some flavin-dependent enzymes are either known or potentially involve radical pairs. Here, we have investigated the magnetic field sensitivity of a number of flavoenzymes with important cellular roles. We also investigated the magnetic field sensitivity of a model system involving stepwise reduction of a flavin analogue by a nicotinamide analogue-a reaction known to proceed via a radical pair. Under the experimental conditions used, magnetic field sensitivity was not observed in the reaction kinetics from stopped-flow measurements in any of the systems studied. Although widely implicated in radical pair chemistry, we conclude that thermally driven, flavoenzyme-catalysed reactions are unlikely to be influenced by exposure to external magnetic fields. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
WP5 In vitro |
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UNIBAS @ david.schuermann @ |
Serial |
633 |
|
| Permanent link to this record |
