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Author  |
Jin, Y.B.; Choi, S.-H.; Lee, J.S.; Kim, J.-K.; Lee, J.-W.; Hong, S.-C.; Myung, S.H.; Lee, Y.-S. |
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Title |
Absence of DNA damage after 60-Hz electromagnetic field exposure combined with ionizing radiation, hydrogen peroxide, or c-Myc overexpression |
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Journal Article |
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2014 |
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Radiation and environmental biophysics |
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53 |
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1 |
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93-101 |
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Keywords |
combined; extremely low frequency á; tail moment for dna; treatment á comet olive |
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Abstract |
The principal objective of this study was to assess the DNA damage in a normal cell line system after exposure to 60 Hz of extremely low frequency magnetic field (ELF-MF) and particularly in combination with various external factors, via comet assays. NIH3T3 mouse fibroblast cells, WI-38 human lung fibroblast cells, L132 human lung epithelial cells, and MCF10A human mammary gland epithelial cells were exposed for 4 or 16 h to a 60-Hz, 1 mT uniform magnetic field in the presence or absence of ionizing radiation (IR, 1 Gy), H(2)O(2) (50 μM), or c-Myc oncogenic activation. The results obtained showed no significant differences between the cells exposed to ELF-MF alone and the unexposed cells. Moreover, no synergistic or additive effects were observed after 4 or 16 h of pre-exposure to 1 mT ELF-MF or simultaneous exposure to ELF-MF combined with IR, H(2)O(2), or c-Myc activation. |
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WP5 In vitro |
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UNIBAS @ david.schuermann @ |
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559 |
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