|
|
Razavi, S., Salimi, M., Shahbazi-Gahrouei, D., Karbasi, S., & Kermani, S. (2014). Extremely low-frequency electromagnetic field influences the survival and proliferation effect of human adipose derived stem cells. Advanced biomedical research, 3, 25.
Abstract: BACKGROUND: Extremely low-frequency electromagnetic fields (ELF-EMF) can effect on biological systems and alters some cell functions like proliferation rate. Therefore, we aimed to attempt the evaluation effect of ELF-EMF on the growth of human adipose derived stem cells (hADSCs). MATERIALS AND METHODS: ELF-EMF was generated by a system including autotransformer, multi-meter, solenoid coils, teslameter and its probe. We assessed the effect of ELF-EMF with intensity of 0.5 and 1 mT and power line frequency 50 Hz on the survival of hADSCs for 20 and 40 min/day for 7 days by MTT assay. One-way analysis of variance was used to assessment the significant differences in groups. RESULTS: ELF-EMF has maximum effect with intensity of 1 mT for 20 min/day on proliferation of hADSCs. The survival and proliferation effect (PE) in all exposure groups were significantly higher than that in sham groups (P < 0.05) except in group of 1 mT and 40 min/day. CONCLUSION: Our results show that between 0.5 m and 1 mT ELF-EMF could be enhances survival and PE of hADSCs conserving the duration of exposure.
|
|
|
|
Vicente-Duenas, C., Abollo-Jimenez, F., Ruiz-Roca, L., Alonso-Escudero, E., Jimenez, R., Cenador, M. B. G., et al. (2010). The age of the target cell affects B-cell leukaemia malignancy. Aging (Albany NY), 2(12), 908–913.
Abstract: The incidence, malignancy and treatment resistance of many types of human B-cell leukaemias (B-ALL) are directly related to patient age. A major obstacle to elucidate the contribution of age to the development and evolution of leukaemias is the lack of appropriate mouse models where precise control of the timing of oncogene expression is possible. Here we present proof-of-principle experiments showing how a conditional transgenic mouse model of BCR-ABLp190-driven B-ALL offers the opportunity to test the hypothesis that the age of the leukemic cells-of-origin of B-ALL influences B-ALL malignancy. B-ALLs generated from 12- and 20-month-old progenitors gave rise to a more invasive B-ALL than the one developed from 4-month old precursors. This was evidenced by survival analysis revealing the increased malignancy of B-ALLs generated from 20 or 12-month-old transformed progenitors compared with the 4-month equivalents (median survival of 88 days versus 50.5 and 33 days, respectively). Our study shows that the age of target cells at the time of transformation affects B-ALL malignancy.
Keywords: Age Factors; Animals; Bone Marrow Transplantation; *Cell Aging; Cell Line; Cell Survival; Fusion Proteins, bcr-abl/genetics/metabolism; Genes, abl; Humans; Leukemia, B-Cell/genetics/metabolism/*pathology; Leukemia, Experimental/genetics/metabolism/*pathology; Mice; Mice, Transgenic; Neoplasm Invasiveness; Neoplastic Stem Cells/metabolism/*pathology
|
|
|
|
Mónica Noemà Jiménez-GarcÃa and Juan José Godina-Nava. (2012). Possible action mechanism of the electromagnetic fields in the liver cancer development: A mathematical proposal. AIP Conference Proceedings, 1420(1), 65–70.
Abstract: ABSTRACT
Currently it is known that electromagnetic field exposure can induce biological changes, although the precise effects and action mechanism of the interaction between the electromagnetic field and biological systems are not well understood. In this work we propose a possible action mechanism, concerning the effect that the extremely low frequency electromagnetic field exposure has on the early stage of liver cancer development. The model is developed studying the phenomena called oxidative stress that it appears after it is applied a carcinogenic agent used to induce hepatic cancer chemically in an experimental animal model. This physical-chemical process involves the movement of magnetic field dependent free charged particles, called free radicals. We will consider the use of the radical pairs theory as a framework, in which we will describe the spin density operator evolution by implementing the stochastic Liouville equation with hyperfine interaction. This describes how the selectivity of the interaction between spin states of the free radicals with the applied electromagnetic field, influences the development of pre-neoplastic lesions in the liver.
Keywords: Electromagnetic Fields, Oxidative Stress, Radical Pairs, Hepatocarcinogenesis
|
|
|
|
Hug, K., Grize, L., Seidler, A., Kaatsch, P., & Schuz, J. (2010). Parental Occupational Exposure to Extremely Low Frequency Magnetic Fields and Childhood Cancer: A German Case-Control Study. American Journal of Epidemiology, 171(1), 27–35.
|
|
|
|
Schuz, J., Svendsen, A. L., Linet, M. S., McBride, M. L., Roman, E., Feychting, M., et al. (2007). Nighttime Exposure to Electromagnetic Fields and Childhood Leukemia: An Extended Pooled Analysis. American Journal of Epidemiology, 166(3), 263–269.
|
|
